TY - JOUR
T1 - Heparin and carboxymethylchitosan metal nanoparticles
T2 - An evaluation of their cytotoxicity
AU - Bava, Adriana
AU - Cappellini, Francesca
AU - Pedretti, Elisa
AU - Rossi, Federica
AU - Caruso, Enrico
AU - Vismara, Elena
AU - Chiriva-Internati, Maurizio
AU - Bernardini, Giovanni
AU - Gornati, Rosalba
PY - 2013
Y1 - 2013
N2 - In the search for noninvasive diagnostic techniques and new therapies, "nanosystems", which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics.
AB - In the search for noninvasive diagnostic techniques and new therapies, "nanosystems", which are capable of binding and targeting bioactive molecules, are becoming increasingly important. In this context, biocompatible coatings are gaining interest, not only for their biological effects but also because they are considered capable to mask nanoparticle toxicity. In this work, we have compared the toxicity of nanoparticles coated with heparin and carboxymethylchitosan in the SKOV-3 cell line. Our results indicate that heparin and carboxymethylchitosan coatings do not guarantee the decrease of nanoparticle intrinsic toxicity which is often envisaged. Nonetheless, these coatings provide the opportunity for further functionalization with a variety of biomolecules for their use in theranostics.
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U2 - 10.1155/2013/314091
DO - 10.1155/2013/314091
M3 - Article
C2 - 23509708
AN - SCOPUS:84874843536
SN - 2314-6133
VL - 2013
JO - BioMed research international
JF - BioMed research international
M1 - 314091
ER -