TY - CHAP
T1 - Hepatocellular carcinoma biology
AU - Blechacz, Boris
AU - Mishra, Lopa
PY - 2013
Y1 - 2013
N2 - Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy. Its incidence and prevalence is globally heterogeneous with the highest rates in Southeast Asia and Sub-Saharan Africa. In Western Industry nations, its incidence has significantly increased throughout the previous three decades. Its global heterogeneity is in part a reflection of the global distribution of its risk factors. Its prognosis is dismal with a 5-year survival of 11 %. The only potentially curative treatment is surgical with either resection or orthotopic liver transplantation. However, the majority of HCC patients are diagnosed at an advanced stage at which surgical therapies are not feasible. HCC is considered chemotherapy-resistanta characteristic thought to be mediated in part through stem-like tumor initiating cells (STICs). Recent studies have provided significant insights in the hepatocarcinogenesis and the molecular signaling pathways of this malignancy resulting in the development of novel, molecular targeted therapies with modest therapeutic benefit. Our growing understanding of the biology of this malignancy will help in the development of novel, molecular-targeted therapies.
AB - Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy. Its incidence and prevalence is globally heterogeneous with the highest rates in Southeast Asia and Sub-Saharan Africa. In Western Industry nations, its incidence has significantly increased throughout the previous three decades. Its global heterogeneity is in part a reflection of the global distribution of its risk factors. Its prognosis is dismal with a 5-year survival of 11 %. The only potentially curative treatment is surgical with either resection or orthotopic liver transplantation. However, the majority of HCC patients are diagnosed at an advanced stage at which surgical therapies are not feasible. HCC is considered chemotherapy-resistanta characteristic thought to be mediated in part through stem-like tumor initiating cells (STICs). Recent studies have provided significant insights in the hepatocarcinogenesis and the molecular signaling pathways of this malignancy resulting in the development of novel, molecular targeted therapies with modest therapeutic benefit. Our growing understanding of the biology of this malignancy will help in the development of novel, molecular-targeted therapies.
UR - http://www.scopus.com/inward/record.url?scp=84868329935&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868329935&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-16037-0_1
DO - 10.1007/978-3-642-16037-0_1
M3 - Chapter
C2 - 22941010
AN - SCOPUS:84868329935
SN - 9783642160363
T3 - Recent Results in Cancer Research
SP - 1
EP - 20
BT - Multidisciplinary Treatment of Hepatocellular Carcinoma
A2 - Vauthey, Jean-Nicolas
A2 - Brouquet, Antoine
ER -