High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma

Yan Feng Chen, Rong Zhen Luo, Yong Li, Bo Kang Cui, Ming Song, An Kui Yang, Wen Kuan Chen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In order to provide a basis for clinical treatment decisions, we explored whether there was a correlation between the expression of COX-2 and P300 and clinical factors in a group of patients with laryngeal squamous cell carcinoma (LSCC). A retrospective analysis of clinicopathological data was conducted in 80 patients with LSCC who presented between January 1997 and December 1998. An immunohistochemistry tissue microarray was conducted of 80 surgically resected LSCC and 20 adjacent normal tissue specimens. Survival analysis and Kaplan-Meier curves were used to compare the effects of clinicopathological factors on survival. The Cox model was applied for multivariate analysis. The expression level of COX-2/P300 in LSCC tissues and adjacent normal tissues were 47.5/50.0 versus 0.0/15.0 %. The expression of COX-2 and P300 was correlated with higher T category, N category, clinical staging, histological grade and recurrence (P < 0.05). P300 expression was correlated with COX-2 expression (P < 0.05). Univariate survival analysis showed that P300, COX-2, N category, clinical staging and recurrence factors were closely correlated with unfavorable survival (P < 0.05). Multivariate analysis showed that COX-2 expression, histological grade and recurrence were independent prognostic factors for LSCC. High expression levels of COX-2 and P300 indicated poor survival outcomes for patients with LSCC.

Original languageEnglish (US)
Pages (from-to)1009-1017
Number of pages9
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume270
Issue number3
DOIs
StatePublished - Mar 1 2013

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Squamous Cell Carcinoma
Survival
Survival Analysis
Recurrence
Multivariate Analysis
Proportional Hazards Models
Immunohistochemistry
Therapeutics

Keywords

  • COX-2
  • Laryngeal squamous cell carcinoma (LSCC)
  • P300
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma. / Chen, Yan Feng; Luo, Rong Zhen; Li, Yong; Cui, Bo Kang; Song, Ming; Yang, An Kui; Chen, Wen Kuan.

In: European Archives of Oto-Rhino-Laryngology, Vol. 270, No. 3, 01.03.2013, p. 1009-1017.

Research output: Contribution to journalArticle

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