High PD-L1 expression is closely associated with tumor-infiltrating lymphocytes and leads to good clinical outcomes in Chinese triple negative breast cancer patients

Ni Jiati AiErken, Hui Juan Shi, Yu Zhou, Nan Shao, Jin Zhang, Yawei Shi, Zhong Yu Yuan, Ying Lin

    Research output: Contribution to journalArticle

    16 Scopus citations

    Abstract

    Background: To investigate the role of Programmed death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) in tumor recurrence and metastasis of Chinese patients suffering from triple negative breast cancer (TNBC). Methods: PD-L1 immunohistochemistry was performed on 215 TNBCs. Also, the prevalence of TILs correlated the expression of PD-L1 and TILs with clinical outcomes. Kaplan-Meier and the model analyses of univariate Cox proportional hazards were utilized to compare the survival of patients with positive PD-L1 expression with those with negative PD-L1 expression. Results: The median follow-up time was 67.7 months (range: 7-159 months). PD-L1-positive breast cancer patients had significantly longer disease-free survival (DFS) and Overall survival (OS) compared with PD-L1-negative patients (P=0.046; P=0.019) in TNBC. The presence of increased stromal lymphocytic infiltrates (STILs) was significantly associated with overall survival (P=0.026). The model analysis of univariate Cox proportional hazards showed that PD-L1 and STILs were independent prognostic factors for tumor prognosis. Conclusions: Our study found that high levels of PD-L1 could be expressed in TNBC, which was correlated with the prevalence of TILs.

    Original languageEnglish (US)
    Pages (from-to)1172-1179
    Number of pages8
    JournalInternational journal of biological sciences
    Volume13
    Issue number9
    DOIs
    StatePublished - Sep 5 2017

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    Keywords

    • Breast cancer
    • PD-L1
    • Prognosis
    • TIL
    • TNBC

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Developmental Biology
    • Cell Biology

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