High prevalence of autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes: Concept of autoimmune exocrinopathy and endocrinopathy of the pancreas

Takao Taniguchi, Kazuichi Okazaki, Motozumi Okamoto, Shuji Seko, Junnya Tanaka, Kazushige Uchida, Kazuaki Nagashima, Takeshi Kurose, Yuichiro Yamada, Tsutomu Chiba, Yutaka Seino

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    55 Scopus citations

    Abstract

    Introduction: Dysfunction of the exocrine as well as the endocrine pancreas has been reported in type 1 diabetes. Lymphocytic infiltration of the exocrine pancreas is observed in approximately half of Japanese type 1 diabetic patients. Aims: To investigate the involvement of autoimmunity against the exocrine pancreas in type 1 diabetes. Methodology: We examined autoantibodies against human carbonic anhydrase II (ACA) and lactoferrin (ALF), antigens in the pancreatic duct cells and the pancreatic acinus, respectively, in 43 type 1 diabetic patients and 20 type 2 diabetic patients using the enzyme-linked immunosorbent assay method. Results: Of 43 type 1 diabetic patients, ACA was detected in 28 patients (65%) and ALF was detected in 29 patients (67%). One or both of the antibodies were detected in 33 type 1 diabetic patients (77%). In contrast, neither ACA nor ALF were detected in type 2 diabetic patients. Conclusions: The high prevalence of both ACA and ALF strongly suggests the involvement of autoimmunity against the exocrine pancreas as well as the endocrine pancreas in some type 1 diabetic patients. We propose that these conditions be referred to as autoimmune exocrinopathy and endocrinopathy of the pancreas.

    Original languageEnglish (US)
    Pages (from-to)26-30
    Number of pages5
    JournalPancreas
    Volume27
    Issue number1
    DOIs
    StatePublished - Jul 1 2003

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    Keywords

    • Autoantibody
    • Autoimmune pancreatitis
    • Exocrine gland
    • Type 1 diabetes

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Hepatology
    • Endocrinology

    Cite this

    Taniguchi, T., Okazaki, K., Okamoto, M., Seko, S., Tanaka, J., Uchida, K., Nagashima, K., Kurose, T., Yamada, Y., Chiba, T., & Seino, Y. (2003). High prevalence of autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes: Concept of autoimmune exocrinopathy and endocrinopathy of the pancreas. Pancreas, 27(1), 26-30. https://doi.org/10.1097/00006676-200307000-00004