Abstract
Optical contrast is sensitive to physiological parameters, such as the oxygen saturation and total concentration of hemoglobin, in biological tissues. Photoacoustic tomography is based on the high optical contrast yet utilizing the high ultrasonic resolution. Our work in this emerging area of research will be summarized in this invited talk. In this technology, a diffraction-based inverse-source problem is solved in the image reconstruction, for which we developed the rigorous reconstruction theory. We implemented a prototype and accomplished non-invasive transdermal and transcranial functional imaging of small-animal brains in vivo. Changes in the cerebral blood oxygenation and blood volume of a rat, as a result of the alternation from hyperoxia to hypoxia, were imaged successfully.
| Original language | English (US) |
|---|---|
| Article number | ThC4 |
| Pages (from-to) | 767-768 |
| Number of pages | 2 |
| Journal | Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS |
| Volume | 2 |
| State | Published - 2004 |
| Event | 2004 IEEE LEOS Annual Meeting Conference Proceedings, LEOS 2004 - Rio Grande, Puerto Rico Duration: Nov 7 2004 → Nov 11 2004 |
Keywords
- Inverse-source reconstruction
- Optical contrast
- Oxygen saturation of hemoglobin
- Photoacoustic tomography
- Ultrasonic resolution
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Electrical and Electronic Engineering