Highlights on mechanisms of drugs targeting MDSCs: providing a novel perspective on cancer treatment

Wei Pan, Qian Sun, Yang Wang, Jian Wang, Shui Cao, Xiubao Ren

    Research output: Contribution to journalReview article

    7 Scopus citations

    Abstract

    The hallmark of tumor microenvironment is that it makes up of numerous immunomodulatory cells and factors which exert essential roles in immunoprotection and immunosuppression in addition to tumor cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells reported to promote immunosuppression and angiogenesis and facilitate tumor metastasis and invasion. The wide scope of MDSCs functional activities make these cells promising targets for effective cancer treatments. In this review, we briefly discuss the origin, subpopulation, and functions of MDSCs, as well as the potential to target these cells for therapeutic benefit. We focus on the underlying molecular mechanisms of these drugs targeting MDSCs, mainly from the standpoint of molecules related to drug targets.

    Original languageEnglish (US)
    Pages (from-to)3159-3169
    Number of pages11
    JournalTumor Biology
    Volume36
    Issue number5
    DOIs
    StatePublished - May 28 2015

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    Keywords

    • Functional regulation
    • MDSCs
    • Mechanisms
    • Subpopulation
    • Therapeutic implication
    • Tumor microenvironment

    ASJC Scopus subject areas

    • Cancer Research

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