Hippo signaling: Growth control and beyond

Georg Halder, Randy L. Johnson

Research output: Contribution to journalReview articlepeer-review

845 Scopus citations

Abstract

The Hippo pathway has emerged as a conserved signaling pathway that is essential for the proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms of signal transduction of the core kinases Hippo/Mst and Warts/Lats are relatively well understood, less is known about the upstream inputs of the pathway and about the downstream cellular and developmental outputs. Here, we review recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development. We also discuss the expanding diversity of Hippo signaling functions during development, discoveries that shed light on a complex regulatory system and provide exciting new insights into the elusive mechanisms that regulate organ growth and regeneration.

Original languageEnglish (US)
Pages (from-to)9-22
Number of pages14
JournalDevelopment
Volume138
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • Cell signaling
  • Drosophila
  • Mouse development
  • Organ growth control
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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