Hippo signaling instructs ectopic but not normal organ growth

W. Kowalczyk, L. Romanelli, M. Atkins, H. Hillen, C. Bravo González-Blas, J. Jacobs, J. Xie, S. Soheily, E. Verboven, I. M. Moya, S. Verhulst, M. de Waegeneer, L. Sansores-Garcia, L. van Huffel, R. L. Johnson, L. A. van Grunsven, S. Aerts, G. Halder

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The Hippo signaling pathway is widely considered a master regulator of organ growth because of the prominent overgrowth phenotypes caused by experimental manipulation of its activity. Contrary to this model, we show here that removing Hippo transcriptional output did not impair the ability of the mouse liver and Drosophila eyes to grow to their normal size. Moreover, the transcriptional activity of the Hippo pathway effectors Yap/Taz/Yki did not correlate with cell proliferation, and hyperactivation of these effectors induced gene expression programs that did not recapitulate normal development. Concordantly, a functional screen in Drosophila identified several Hippo pathway target genes that were required for ectopic overgrowth but not normal growth. Thus, Hippo signaling does not instruct normal growth, and the Hippo-induced overgrowth phenotypes are caused by the activation of abnormal genetic programs.

Original languageEnglish (US)
Article numbereabg3679
Issue number6621
StatePublished - Nov 18 2022

ASJC Scopus subject areas

  • General


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