Abstract
Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications. Developmental aberrations in mice and certain human cancers are associated with HAT mutations, further highlighting the importance of these enzymes to normal cell growth and differentiation.
Original language | English (US) |
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Pages (from-to) | 155-161 |
Number of pages | 7 |
Journal | Current Opinion in Genetics and Development |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1 2001 |
ASJC Scopus subject areas
- Genetics
- Developmental Biology