Histone acetyltransferases: Function, structure, and catalysis

Ronen Marmorstein, Sharon Y. Roth

Research output: Contribution to journalReview articlepeer-review

328 Scopus citations

Abstract

Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications. Developmental aberrations in mice and certain human cancers are associated with HAT mutations, further highlighting the importance of these enzymes to normal cell growth and differentiation.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume11
Issue number2
DOIs
StatePublished - Apr 1 2001

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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