Abstract
This chapter focuses on one aspect of remodeling, histone acetylation that is central to gene activation. The transcriptional requirements of embryos are drastically different than those of adult organisms. Transitions from totipotent stem cells to specialized, differentiated cells and tissues involve orderly progressions of gene activation and repression. The importance of chromatin remodeling to developmental programs of gene expression is increasingly clear. Both higher order structures and individual nucleosomes inhibit transcription. Each histone contains a large hydrophobic region that associates with the other histones to make up the core of the nucleosome and an unstructured N-terminal hydrophilic tail that protrudes from the nucleosome core particle.
Original language | English (US) |
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Title of host publication | Adult and Fetal |
Publisher | Elsevier Inc. |
Pages | 105-113 |
Number of pages | 9 |
Volume | 2 |
ISBN (Electronic) | 9780080533735 |
ISBN (Print) | 9780124366435 |
DOIs | |
State | Published - Sep 14 2004 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology