Histone methylation modifiers in cellular signaling pathways

Hunain Alam, Bingnan Gu, Min Gyu Lee

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations

Abstract

Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels of various non-histone proteins, such as effector proteins that play critical roles in cellular signaling networks. Dysregulated histone methylation modifiers alter expression of oncogenes and tumor suppressor genes and change methylation states of effector proteins, frequently resulting in aberrant cellular signaling cascades and cellular transformation. In this review, we summarize the role of histone methylation modifiers in regulating the following signaling pathways: NF-κB, RAS/RAF/MEK/MAPK, PI3K/Akt, Wnt/β-catenin, p53, and ERα.

Original languageEnglish (US)
Pages (from-to)4577-4592
Number of pages16
JournalCellular and Molecular Life Sciences
Volume72
Issue number23
DOIs
StatePublished - Aug 25 2015

Keywords

  • Histone demethylase
  • Histone methylation
  • Histone methyltransferase
  • Oncogenic signaling
  • Tumor suppressor pathway

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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