TY - JOUR
T1 - Histone modifications and the DNA double-strand break response
AU - Van, Hieu T.
AU - Santos, Margarida A.
N1 - Funding Information:
We thank Drs. R. Behringer and R. Miller and the members of the Santos Lab for critical reading and suggestions. This work is supported by a Cancer Prevention Research Institute of Texas Recruitment of First-time Tenure-Track Faculty Award (RR150039), an Andrew Sabin Family Foundation Fellow Award and an American Society of Hematology (ASH) Junior Faculty Scholar Award to MAS.
Funding Information:
This work was supported by the American Society of Hematology [NA]; Andrew Sabin Family Foundation [NA] and Cancer Prevention Research Institute of Texas [RR150039].
Funding Information:
This work was supported by the American Society of Hematology [NA]; Andrew Sabin Family Foundation [NA] and Cancer Prevention Research Institute of Texas [RR150039]. We thank Drs. R. Behringer and R. Miller and the members of the Santos Lab for critical reading and suggestions. This work is supported by a Cancer Prevention Research Institute of Texas Recruitment of First-time Tenure-Track Faculty Award (RR150039), an Andrew Sabin Family Foundation Fellow Award and an American Society of Hematology (ASH) Junior Faculty Scholar Award to MAS.
Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/11/17
Y1 - 2018/11/17
N2 - The timely and precise repair of DNA damage, or more specifically DNA double-strand breaks (DSBs)–the most deleterious DNA lesions, is crucial for maintaining genome integrity and cellular homeostasis. An appropriate cellular response to DNA DSBs requires the integration of various factors, including the post-translational modifications (PTMs) of chromatin and chromatin-associated proteins. Notably, the PTMs of histones have been shown to play a fundamental role in initiating and regulating cellular responses to DNA DSBs. Here we review the role of the major histone PTMs, including phosphorylation, ubiquitination, methylation and acetylation, and their interactions during DNA DSB-induced responses.
AB - The timely and precise repair of DNA damage, or more specifically DNA double-strand breaks (DSBs)–the most deleterious DNA lesions, is crucial for maintaining genome integrity and cellular homeostasis. An appropriate cellular response to DNA DSBs requires the integration of various factors, including the post-translational modifications (PTMs) of chromatin and chromatin-associated proteins. Notably, the PTMs of histones have been shown to play a fundamental role in initiating and regulating cellular responses to DNA DSBs. Here we review the role of the major histone PTMs, including phosphorylation, ubiquitination, methylation and acetylation, and their interactions during DNA DSB-induced responses.
KW - DNA damage
KW - Histones
KW - chromatin MODIFICATIONS
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U2 - 10.1080/15384101.2018.1542899
DO - 10.1080/15384101.2018.1542899
M3 - Review article
C2 - 30394812
AN - SCOPUS:85057558794
SN - 1538-4101
VL - 17
SP - 2399
EP - 2410
JO - Cell Cycle
JF - Cell Cycle
IS - 21-22
ER -