HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies

Gilberto Vargas-Alarcón, Adrián Garcia, Susana Bahena, Héctor Melín-Aldana, Felipe Andrade, Graciela Ibañez-De-Kasep, Jorge Alcocer-Varela, Donato Alarcón-Segovia, Julio Granados

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Abstract

Objectives-To analyse major histocompatibility complex (MHC) haplotypes in Mexican mestizo patients with seronegative spondyloarthropathies (SSpA) and normal controls, to discover if there are other antigens, besides B27, in the HLA region that might show association with the disease. Methods-The study included 100 Mexican mestizo patients with SSpA and 200 of their first degree relatives. These groups were compared with 85 ethnically matched controls. The class I and class III MHC antigens were obtained by standard methods. The significance of differences between patients and controls was tested by χ2 analysis; linkage disequilibrium among the different alleles in each haplotype was estimated by computing delta values. Results-We found a significantly increased frequency of the HLA-B27 antigen (pcorr. = 1 x 10 -5, odds ratio (OR) = 33.4, 95% confidence interval (CI) = 9-3-142.0). In the group of 45 SSpA patients negative for the B27 antigen, independent increased frequencies ofHLA-B49 antigen (Pcorr. = 0-03, OR = 6-5, 95% CI = 1-5-32-8)) and the FC31 complotype (pco,. = 0*04, OR=3-7, 95% CI= 12-11-1) were found. Significant delta values were obtained for the [B27;SC30] haplotype (p = 0.0005) but not for haplotypes marked by the FC31 complotype. HLA-B antigens on the homologous chromosome in B27 positive patients were mainly HLA-B51 (18%) and HLA-B60 (16%); however, the observed genotypes B27/B51 and B27/B60 were not significantly different than expected from the allele frequencies alone. Conclusions-These data suggest that in Mexicans additional genes within the MHC region besides the HLA-B27 antigen, might be related to the genetic susceptibility for developing SSpA. Relevant antigens included the HLA-B49 and the FC31 complotype.

Original languageEnglish (US)
Pages (from-to)755-758
Number of pages4
JournalAnnals of the rheumatic diseases
Volume53
Issue number11
DOIs
StatePublished - Jan 1 1994

Fingerprint

Spondylarthropathies
HLA-B Antigens
HLA-B27 Antigen
Alleles
Haplotypes
Antigens
Major Histocompatibility Complex
Odds Ratio
Confidence Intervals
HLA-B51 Antigen
Histocompatibility Antigens
Linkage Disequilibrium
Genetic Predisposition to Disease
Chromosomes
Gene Frequency
Genes
Genotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vargas-Alarcón, G., Garcia, A., Bahena, S., Melín-Aldana, H., Andrade, F., Ibañez-De-Kasep, G., ... Granados, J. (1994). HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies. Annals of the rheumatic diseases, 53(11), 755-758. https://doi.org/10.1136/ard.53.11.755

HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies. / Vargas-Alarcón, Gilberto; Garcia, Adrián; Bahena, Susana; Melín-Aldana, Héctor; Andrade, Felipe; Ibañez-De-Kasep, Graciela; Alcocer-Varela, Jorge; Alarcón-Segovia, Donato; Granados, Julio.

In: Annals of the rheumatic diseases, Vol. 53, No. 11, 01.01.1994, p. 755-758.

Research output: Contribution to journalArticle

Vargas-Alarcón, G, Garcia, A, Bahena, S, Melín-Aldana, H, Andrade, F, Ibañez-De-Kasep, G, Alcocer-Varela, J, Alarcón-Segovia, D & Granados, J 1994, 'HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies', Annals of the rheumatic diseases, vol. 53, no. 11, pp. 755-758. https://doi.org/10.1136/ard.53.11.755
Vargas-Alarcón G, Garcia A, Bahena S, Melín-Aldana H, Andrade F, Ibañez-De-Kasep G et al. HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies. Annals of the rheumatic diseases. 1994 Jan 1;53(11):755-758. https://doi.org/10.1136/ard.53.11.755
Vargas-Alarcón, Gilberto ; Garcia, Adrián ; Bahena, Susana ; Melín-Aldana, Héctor ; Andrade, Felipe ; Ibañez-De-Kasep, Graciela ; Alcocer-Varela, Jorge ; Alarcón-Segovia, Donato ; Granados, Julio. / HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies. In: Annals of the rheumatic diseases. 1994 ; Vol. 53, No. 11. pp. 755-758.
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abstract = "Objectives-To analyse major histocompatibility complex (MHC) haplotypes in Mexican mestizo patients with seronegative spondyloarthropathies (SSpA) and normal controls, to discover if there are other antigens, besides B27, in the HLA region that might show association with the disease. Methods-The study included 100 Mexican mestizo patients with SSpA and 200 of their first degree relatives. These groups were compared with 85 ethnically matched controls. The class I and class III MHC antigens were obtained by standard methods. The significance of differences between patients and controls was tested by χ2 analysis; linkage disequilibrium among the different alleles in each haplotype was estimated by computing delta values. Results-We found a significantly increased frequency of the HLA-B27 antigen (pcorr. = 1 x 10 -5, odds ratio (OR) = 33.4, 95{\%} confidence interval (CI) = 9-3-142.0). In the group of 45 SSpA patients negative for the B27 antigen, independent increased frequencies ofHLA-B49 antigen (Pcorr. = 0-03, OR = 6-5, 95{\%} CI = 1-5-32-8)) and the FC31 complotype (pco,. = 0*04, OR=3-7, 95{\%} CI= 12-11-1) were found. Significant delta values were obtained for the [B27;SC30] haplotype (p = 0.0005) but not for haplotypes marked by the FC31 complotype. HLA-B antigens on the homologous chromosome in B27 positive patients were mainly HLA-B51 (18{\%}) and HLA-B60 (16{\%}); however, the observed genotypes B27/B51 and B27/B60 were not significantly different than expected from the allele frequencies alone. Conclusions-These data suggest that in Mexicans additional genes within the MHC region besides the HLA-B27 antigen, might be related to the genetic susceptibility for developing SSpA. Relevant antigens included the HLA-B49 and the FC31 complotype.",
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T1 - HLA-B alleles and complotypes in Mexican patients with seronegative spondyloarthropathies

AU - Vargas-Alarcón, Gilberto

AU - Garcia, Adrián

AU - Bahena, Susana

AU - Melín-Aldana, Héctor

AU - Andrade, Felipe

AU - Ibañez-De-Kasep, Graciela

AU - Alcocer-Varela, Jorge

AU - Alarcón-Segovia, Donato

AU - Granados, Julio

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N2 - Objectives-To analyse major histocompatibility complex (MHC) haplotypes in Mexican mestizo patients with seronegative spondyloarthropathies (SSpA) and normal controls, to discover if there are other antigens, besides B27, in the HLA region that might show association with the disease. Methods-The study included 100 Mexican mestizo patients with SSpA and 200 of their first degree relatives. These groups were compared with 85 ethnically matched controls. The class I and class III MHC antigens were obtained by standard methods. The significance of differences between patients and controls was tested by χ2 analysis; linkage disequilibrium among the different alleles in each haplotype was estimated by computing delta values. Results-We found a significantly increased frequency of the HLA-B27 antigen (pcorr. = 1 x 10 -5, odds ratio (OR) = 33.4, 95% confidence interval (CI) = 9-3-142.0). In the group of 45 SSpA patients negative for the B27 antigen, independent increased frequencies ofHLA-B49 antigen (Pcorr. = 0-03, OR = 6-5, 95% CI = 1-5-32-8)) and the FC31 complotype (pco,. = 0*04, OR=3-7, 95% CI= 12-11-1) were found. Significant delta values were obtained for the [B27;SC30] haplotype (p = 0.0005) but not for haplotypes marked by the FC31 complotype. HLA-B antigens on the homologous chromosome in B27 positive patients were mainly HLA-B51 (18%) and HLA-B60 (16%); however, the observed genotypes B27/B51 and B27/B60 were not significantly different than expected from the allele frequencies alone. Conclusions-These data suggest that in Mexicans additional genes within the MHC region besides the HLA-B27 antigen, might be related to the genetic susceptibility for developing SSpA. Relevant antigens included the HLA-B49 and the FC31 complotype.

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