Abstract
An estimated 8,490 Americans were diagnosed as having Hodgkin lymphoma (HL) in 2010 [1]. HL is a B-cell lymphoma that arises from germinal center or post-germinal center B cells. Two types of classic HL (cHL) make up 95 % of HL diagnoses; in contrast, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is rare and has distinct pathologic features. cHL is unique in that the CD30-positive Reed-Sternberg (RS) cells often make up less than 1 % of the tumor and are surrounded by a rich microenvironment, including CD20-positive reactive B cells that are believed to provide survival signals to the RS cells.
Original language | English (US) |
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Title of host publication | 60 Years of Survival Outcomes at the University of Texas MD Anderson Cancer Center |
Publisher | Springer New York |
Pages | 225-239 |
Number of pages | 15 |
ISBN (Electronic) | 9781461451976 |
ISBN (Print) | 1461451965, 9781461451969 |
DOIs | |
State | Published - Aug 1 2012 |
ASJC Scopus subject areas
- General Medicine