Hodgkin lymphoma

Michelle Fanale, Bouthaina Dabaja, Uday Popat, Paolo Anderlini, Anas Younes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

An estimated 8,490 Americans were diagnosed as having Hodgkin lymphoma (HL) in 2010 [1]. HL is a B-cell lymphoma that arises from germinal center or post-germinal center B cells. Two types of classic HL (cHL) make up 95 % of HL diagnoses; in contrast, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is rare and has distinct pathologic features. cHL is unique in that the CD30-positive Reed-Sternberg (RS) cells often make up less than 1 % of the tumor and are surrounded by a rich microenvironment, including CD20-positive reactive B cells that are believed to provide survival signals to the RS cells.

Original languageEnglish (US)
Title of host publication60 Years of Survival Outcomes at the University of Texas MD Anderson Cancer Center
PublisherSpringer New York
Pages225-239
Number of pages15
ISBN (Electronic)9781461451976
ISBN (Print)1461451965, 9781461451969
DOIs
StatePublished - Aug 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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