TY - JOUR
T1 - Hormonal based treatment of ovarian anaplastic ependymoma with anastrozole
AU - Gorski, Justin Wayne
AU - Taylor, Jolyn Sharpe
AU - Zhang, Jing
AU - Liu, Jinsong
AU - Jazaeri, Amir Anthony
N1 - Publisher Copyright:
© 2017 The Authors
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Objective Ovarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as estrogen and progesterone receptors (ER/PR). Case A 29-year-old woman presented with incidental finding of large bilateral adnexal masses and elevated CA 125. Biopsy proved anaplastic ovarian ependymoma with high ER/PR expression. She underwent sub-optimal surgical debulking followed by adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP) which resulted in a partial response. Due to extensive residual disease she has been maintained on anastrozole for over fifteen months without increased tumor burden. Targeted somatic mutation testing was negative for all high risk clinically useful variants. Conclusion Aromatase inhibitors may be considered in patients with extra-axial anaplastic ependymoma and can produce prolonged stable disease.
AB - Objective Ovarian anaplastic ependymoma is a rare gynecologic malignancy that poses diagnostic and treatment challenges. Treatment of sub-optimally debulked disease usually portends poor prognosis. Molecular testing of tumor specimen can identify more specific targets for additional therapy such as estrogen and progesterone receptors (ER/PR). Case A 29-year-old woman presented with incidental finding of large bilateral adnexal masses and elevated CA 125. Biopsy proved anaplastic ovarian ependymoma with high ER/PR expression. She underwent sub-optimal surgical debulking followed by adjuvant chemotherapy with bleomycin, etoposide and cisplatin (BEP) which resulted in a partial response. Due to extensive residual disease she has been maintained on anastrozole for over fifteen months without increased tumor burden. Targeted somatic mutation testing was negative for all high risk clinically useful variants. Conclusion Aromatase inhibitors may be considered in patients with extra-axial anaplastic ependymoma and can produce prolonged stable disease.
KW - Aromatase inhibitor
KW - Ovarian anaplastic ependymoma
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U2 - 10.1016/j.gore.2017.03.005
DO - 10.1016/j.gore.2017.03.005
M3 - Article
C2 - 28393092
AN - SCOPUS:85016419403
SN - 2211-338X
VL - 20
SP - 93
EP - 96
JO - Gynecologic Oncology Reports
JF - Gynecologic Oncology Reports
ER -