Abstract
Understanding of the genetic basis and molecular pathogenesis of cancer has evolved substantially over the past century. The advent of high-throughput gene sequencing methods has unraveled hundreds of recurrent somatic genetic alterations in various malignancies, either causative or harboring major prognostic and/or predictive implications. Knowledge of these specific changes has dramatically altered diagnostic and therapeutic approaches to cancer, enabling personalized molecular therapies. This article shares approaches to adopting and fine-tuning the practice of molecular diagnostics as an essential component of diagnostic pathology in a tertiary care cancer hospital and proposes methods by which genetic testing in cancer can become standard of care in pathology departments across the nation.
Original language | English (US) |
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Pages (from-to) | 787-792 |
Number of pages | 6 |
Journal | JNCCN Journal of the National Comprehensive Cancer Network |
Volume | 14 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2016 |
ASJC Scopus subject areas
- Oncology