Abstract
Purpose: To evaluate whether human cytomegalovirus (CMV) may play a role in the pathogenesis of benign prostatic hyperplasia. Materials and Methods: We used immunohistochemistry and the polymerase chain reaction (PCR) to evaluate the presence of CMV in normal prostatic tissue (n=12) and BPH tissue (n=21). Results: Immunostaining for CMV in prostatic tissue was negative; however, staining was evident in mononuclear cells seen in the tissues of both groups. With nested PCR, CMV genomic material was demonstrated in 1 tissue specimen from each group (p >0.1). Conclusions: These data suggest that CMV is unlikely to be a significant factor in the pathogenesis of BPH.
Original language | English (US) |
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Pages (from-to) | 542-545 |
Number of pages | 4 |
Journal | Journal of Urology |
Volume | 156 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1996 |
Externally published | Yes |
Keywords
- Cytomegalovirus
- Immunohistochemistry
- Polymerase chain reaction
- Prostatic hyperplasia
ASJC Scopus subject areas
- Urology