Human extrafollicular CD4 + Th cells help memory B cells produce Igs

Sang Taek Kim, Jin Young Choi, Begona Lainez, Vincent P. Schulz, David E. Karas, Eric D. Baum, Jennifer Setlur, Patrick G. Gallagher, Joe Craft

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Follicular helper T (Tfh) cells are necessary for germinal center B cell maturation during primary immune responses; however, the T cells that promote humoral recall responses via memory B cells are less well defined. In this article, we characterize a human tonsillar CD4 + T cell subset with this function. These cells are similar to Tfh cells in terms of expression of the chemokine receptor CXCR5 and the inhibitory receptor PD-1, IL-21 secretion, and expression of the transcription factor BCL6; however, unlike Tfh cells that are located within the B cell follicle and germinal center, they reside at the border of the T cell zone and the B cell follicle in proximity to memory B cells, a position dictated by their unique chemokine receptor expression. They promote memory B cells to produce Abs via CD40L, IL-10, and IL-21. Our results reveal a unique extrafollicular CD4 + T cell subset in human tonsils, which specialize in promoting T cell-dependent humoral recall responses.

Original languageEnglish (US)
Pages (from-to)1359-1372
Number of pages14
JournalJournal of Immunology
Volume201
Issue number5
DOIs
StatePublished - Sep 1 2018

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B-Lymphocytes
Germinal Center
Chemokine Receptors
T-Lymphocyte Subsets
T-Lymphocytes
CXCR5 Receptors
CD40 Ligand
Palatine Tonsil
Helper-Inducer T-Lymphocytes
Interleukin-10
Transcription Factors
interleukin-21

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Kim, S. T., Choi, J. Y., Lainez, B., Schulz, V. P., Karas, D. E., Baum, E. D., ... Craft, J. (2018). Human extrafollicular CD4 + Th cells help memory B cells produce Igs Journal of Immunology, 201(5), 1359-1372. https://doi.org/10.4049/jimmunol.1701217

Human extrafollicular CD4 + Th cells help memory B cells produce Igs . / Kim, Sang Taek; Choi, Jin Young; Lainez, Begona; Schulz, Vincent P.; Karas, David E.; Baum, Eric D.; Setlur, Jennifer; Gallagher, Patrick G.; Craft, Joe.

In: Journal of Immunology, Vol. 201, No. 5, 01.09.2018, p. 1359-1372.

Research output: Contribution to journalArticle

Kim, ST, Choi, JY, Lainez, B, Schulz, VP, Karas, DE, Baum, ED, Setlur, J, Gallagher, PG & Craft, J 2018, ' Human extrafollicular CD4 + Th cells help memory B cells produce Igs ', Journal of Immunology, vol. 201, no. 5, pp. 1359-1372. https://doi.org/10.4049/jimmunol.1701217
Kim, Sang Taek ; Choi, Jin Young ; Lainez, Begona ; Schulz, Vincent P. ; Karas, David E. ; Baum, Eric D. ; Setlur, Jennifer ; Gallagher, Patrick G. ; Craft, Joe. / Human extrafollicular CD4 + Th cells help memory B cells produce Igs In: Journal of Immunology. 2018 ; Vol. 201, No. 5. pp. 1359-1372.
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