Human papillomavirus-58 and -73-associated digital squamous cell carcinoma in a patient with aggressive digital papillary adenocarcinoma

William Depond, Kiyoe Kure, Kamani Lankachandra, Raja Gidwani, Brook V. Nelson, Hannah Zimmerman, Glenn E. Talboy, Roberto Miranda

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Aggressive digital papillary adenocarcinoma (ADPA) is a rare tumor that is considered to arise from eccrine sweat glands of the skin. It occurs predominantly in men with a mean age in the sixth decade. It shows a strong tendency for local recurrence and has the potential to metastasize to distant sites. Prompt diagnosis and regular follow-up are important to ensure the best possible outcome. We discuss a case of recurrent ADPA associated with subsequent squamous cell carcinoma (SCC) in different contralateral digits in a 55-year-old man. One SCC lesion tested positive for human papillomavirus (HPV)-58. HPV-associated digital SCCs have been reported; most cases are HPV-16 positive. This report describes a rare case of an HPV-58-positive invasive digital SCC and an HPV-73-positive SCC in situ associated with ADPA.

Original languageEnglish (US)
Pages (from-to)375-378
Number of pages4
JournalAmerican Journal of Dermatopathology
Volume31
Issue number4
DOIs
StatePublished - Jun 1 2009

Keywords

  • Aggressive digital papillary adenocarcinoma
  • Digital squamous cell carcinoma
  • Human papillomavirus-58
  • Human papillomavirus-73

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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