Hyperbaric oxygen as an adjunctive treatment for zygomycosis

B. V. John, G. Chamilos, D. P. Kontoyiannis

Research output: Contribution to journalEditorialpeer-review

138 Scopus citations

Abstract

Zygomycosis is a rare but emerging mycosis. Because of the sub-optimal efficacy of the standard antifungal treatment for this disease, hyperbaric oxygen (HBO) has been used occasionally as an adjunctive therapeutic modality. A review of 28 published cases of zygomycosis indicates that adjunctive HBO may be beneficial in diabetic patients (94% survival), whereas its benefit in the small group of patients with haematological malignancies or bone marrow transplants is doubtful (33% survival; p 0.02). Prolonged courses of HBO were associated with a higher survival (100% survival; p 0.003). Additional studies are required to assess the optimal timing and dose for HBO treatment.

Original languageEnglish (US)
Pages (from-to)515-517
Number of pages3
JournalClinical Microbiology and Infection
Volume11
Issue number7
DOIs
StatePublished - Jul 2005

Keywords

  • Antifungal therapy
  • Hyperbaric oxygen
  • Immunocompromised patients
  • Mucorales
  • Zygomycosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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