Hyperpigmentation in Megaloblastic Anemia

Seung Hun Lee, Won Soo Lee, Kyu Chuan Whang, Sun Ju Lee, Jae Bock Chung

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    18 Scopus citations


    ABSTRACT: Hyperpigmentation of the hands and feet developed in a 65–year–old Korean woman who had undergone a total gastrectomy and esophagojejunostomy due to early gastric cancer 7 years previously. A diagnosis of megaloblastic anemia due to vitamin B12deficiency was made. In the areas of pigmentation, there were abnormally large nuclei in the keratinocytes. All of these findings were reversible upon the administration of vitamin B12 Ultrastructurally, there were many intracytoplasmic desmosomes, numerous aggregated bundles of tonofilaments, and highly condensed keratohyalin granules. The pathophysiologic mechanism of vitamin B12 deficiency associated with pigmentary disturbances and change of nuclear size is discussed.

    Original languageEnglish (US)
    Pages (from-to)571-575
    Number of pages5
    JournalInternational Journal of Dermatology
    Issue number8
    StatePublished - Jan 1 1988


    ASJC Scopus subject areas

    • Dermatology

    Cite this

    Lee, S. H., Lee, W. S., Whang, K. C., Lee, S. J., & Chung, J. B. (1988). Hyperpigmentation in Megaloblastic Anemia. International Journal of Dermatology, 27(8), 571-575. https://doi.org/10.1111/j.1365-4362.1988.tb02407.x