TY - JOUR
T1 - Hyponatremia with Antidepressant
T2 - A Rare Side Effect from Duloxetine in a Child with Acute Leukemia
AU - Baig, Muhammad Usman
AU - Madden, Kevin
AU - Moody, Karen
N1 - Publisher Copyright:
© Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Duloxetine is indicated for the treatment of chemotherapy-induced neuropathic pain in adults. It is also indicated for anxiety, depression, and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults, but not in pediatrics or pediatric oncology patients. We present the case of a 10-year-old child with acute lymphoblastic leukemia, who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and comorbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.
AB - Duloxetine is indicated for the treatment of chemotherapy-induced neuropathic pain in adults. It is also indicated for anxiety, depression, and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults, but not in pediatrics or pediatric oncology patients. We present the case of a 10-year-old child with acute lymphoblastic leukemia, who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and comorbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.
KW - duloxetine side effect
KW - pediatric acute lymphoblastic leukemia
KW - syndrome of inappropriate antidiuretic hormone secretion
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U2 - 10.1089/jpm.2021.0526
DO - 10.1089/jpm.2021.0526
M3 - Article
C2 - 35537479
AN - SCOPUS:85143644333
SN - 1096-6218
VL - 25
SP - 1884
EP - 1887
JO - Journal of palliative medicine
JF - Journal of palliative medicine
IS - 12
ER -