İçme sularında yüksek nitrat bulunan Akkaraman koyunlarda serum lipid profili ve enzim düzeyleri

In this study, we aimed to determine serum lipid and protein profile and level of creatinine and liver enzymes, LDH, AST and ALP activity in Akkaraman sheep with high nitrate in drinking water. Additionally, spring water nitrate levels were measured from Nevşhir province. Nitrate concentration in water was detected by chromatographic method with Bio LC. Akkaraman sheep serum AST, ALP and LDH enzyme activities and triglyceride, cholesterol, HDL-C, total protein, albumin and creatinine levels were analyzed with autoanalyzer. VLDL-C, LDL-C, globulin and albumin/globulin ratio were obtained with calculation. The spring water samples collected from 34 different regions in Hacibektaş area. Over acceptable nitrate level have found in 74% of them also there were measured 12% over 100mg/L. In Akkaraman sheep with high nitrate in drinking water serum LDH and ALP enzyme activities decreased compare to control group. LDH activity decrement was found statistically significant (p<0.001). Serum triglyceride and cholesterol levels were found significantly higher in control group (p<0.01, p<0.001 respectively). No significant difference was found in HDL level. Serum total protein, VLDL and LDL levels were determined in study group significantly lower than control animals (p<0.05, (p<0.01 and p<0.001 respectively). Consequently, drinking water nitrate levels were detected higher than acceptable limits. Akkaraman sheep with high nitrate in drinking water, blood sample analyses have shown health effects of high nitrate level in consuming water.