Identification of an interfering ligand aptamer for EphB2/3 receptors

Paola Amero, Carla Lucia Esposito, Anna Rienzo, Fortunato Moscato, Silvia Catuogno, Vittorio De Franciscis

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The Eph receptors are transmembrane proteins that belong to the receptor tyrosine kinases superfamily. Elevated Eph/ephrin expression levels have been associated with angiogenesis and tumor vasculature in many types of human cancers, including breast, lung, and prostate cancers, melanoma, and leukemia. In glioblastoma (GBM), the dysregulated expression of Eph receptors and of corresponding ephrin ligands has been associated with higher tumor grade and poor prognosis making them effective targets for therapeutic drugs. In this study, we describe the GL43.T, an anti-Eph aptamer, able to bind at high-affinity EphB3 and EphB2. Moreover, the GL43.T aptamer inhibits the glioma cell vitality and interferes with ephrine-B1 inhibition of chemotactic serum-stimulated cell migration. GL43.T aptamer represents a promising therapeutic molecule for EphB3-dependent cancers.

Original languageEnglish (US)
Pages (from-to)102-110
Number of pages9
JournalNucleic Acid Therapeutics
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery

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