Identification of spontaneous programmed cell death during development of human breast cancer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Breast tumorigenesis proceeds through an accumulation of specific genetic alteration. Breast malignant transformation is dependent not only on the rate of cell production but also on apoptosis, a genetically programmed process of autonomous cell death. We investigated whether breast tumorigenesis involves an altered susceptibility to apoptosis by examining normal breast epithelium and breast cancer samples. We found there is a significant inhibition of spontaneous apoptosis in breast cancer cells compared with normal breast epithelium. The inhibition of apoptosis in breast cancer may contribute to neoplastic transformation.

Original languageEnglish (US)
Pages (from-to)1133-1136
Number of pages4
JournalOncology reports
Volume3
Issue number6
StatePublished - Nov 4 1996

Fingerprint

Human Development
Breast
Cell Death
Breast Neoplasms
Apoptosis
Carcinogenesis
Epithelium
Inhibition (Psychology)

Keywords

  • PCNA
  • apoptosis
  • breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Identification of spontaneous programmed cell death during development of human breast cancer. / Shao, Zhi Ming.

In: Oncology reports, Vol. 3, No. 6, 04.11.1996, p. 1133-1136.

Research output: Contribution to journalArticle

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