TY - JOUR
T1 - Idiopathic Multicentric Osteolysis
AU - Whyte, Michael P.
AU - Murphy, William A.
AU - Kleerekoper, Michael
AU - Teitelbaum, Steven L.
AU - Avioli, Louis V.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1978/4
Y1 - 1978/4
N2 - Genetic, rheumatologic, immunologic, metabolic, and renal studies of a father and son with idiopathic multicentric osteolysis are reported. The disorder appeared through mutation. The father developed symptoms as an infant, his son at age 4 years and 9 months. Both have micrognathia and hypotelorism and were exceptionally tall during the symptomatic phase of their disease. Biopsies of the son's wrist showed normal synovium, encroachment on cartilage by fibrocellular tissue, and both osteoclastic resorption and repair of affected bone. Hydroxyproline in his urine was increased. No immunologic, renal, or other metabolic abnormalities were identified.
AB - Genetic, rheumatologic, immunologic, metabolic, and renal studies of a father and son with idiopathic multicentric osteolysis are reported. The disorder appeared through mutation. The father developed symptoms as an infant, his son at age 4 years and 9 months. Both have micrognathia and hypotelorism and were exceptionally tall during the symptomatic phase of their disease. Biopsies of the son's wrist showed normal synovium, encroachment on cartilage by fibrocellular tissue, and both osteoclastic resorption and repair of affected bone. Hydroxyproline in his urine was increased. No immunologic, renal, or other metabolic abnormalities were identified.
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U2 - 10.1002/art.1780210313
DO - 10.1002/art.1780210313
M3 - Article
C2 - 646835
AN - SCOPUS:0018256744
SN - 0004-3591
VL - 21
SP - 367
EP - 376
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 3
ER -