IL-15: Targeting CD8+ T cells for immunotherapy

A. Diab; A. D. Cohen; O. Alpdogan; Miguel Angel Perales

doi:10.1080/14653240510018037

IL-15: Targeting CD8⁺ T cells for immunotherapy

A. Diab, A. D. Cohen, O. Alpdogan, Miguel Angel Perales

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8⁺ T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8⁺ T cells.

Original language	English (US)
Pages (from-to)	23-35
Number of pages	13
Journal	Cytotherapy
Volume	7
Issue number	1
DOIs	https://doi.org/10.1080/14653240510018037
State	Published - 2005
Externally published	Yes

Keywords

IL-15
Immunotherapy
Tumor
Vaccine

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology
Genetics(clinical)
Cell Biology
Cancer Research
Transplantation

Access to Document

10.1080/14653240510018037

Cite this

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title = "IL-15: Targeting CD8+ T cells for immunotherapy",

abstract = "IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8+ T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8+ T cells.",

keywords = "IL-15, Immunotherapy, Tumor, Vaccine",

author = "A. Diab and Cohen, {A. D.} and O. Alpdogan and Perales, {Miguel Angel}",

note = "Funding Information: Dr Miguel-Angel Perales received support from NIH grant K08CA10260 and the Byrne Fund (MSKCC). Dr Adam Cohen is supported in part by an ASCO Young Investigator Award , the Clinical Scholars Biomedical Research Training Program and grant T32 CA009512 from the National Cancer Institute.",

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T2 - Targeting CD8+ T cells for immunotherapy

AU - Diab, A.

AU - Cohen, A. D.

AU - Alpdogan, O.

AU - Perales, Miguel Angel

N1 - Funding Information: Dr Miguel-Angel Perales received support from NIH grant K08CA10260 and the Byrne Fund (MSKCC). Dr Adam Cohen is supported in part by an ASCO Young Investigator Award , the Clinical Scholars Biomedical Research Training Program and grant T32 CA009512 from the National Cancer Institute.

PY - 2005

Y1 - 2005

N2 - IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8+ T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8+ T cells.

AB - IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8+ T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8+ T cells.

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KW - Immunotherapy

KW - Tumor

KW - Vaccine

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