IL-2 gene C/T polymorphism is associated with prostate cancer

Hsi Chin Wu, Chao Hsiang Chang, Lei Wan, Chao I. Wu, Fuu Jen Tsai, Wen Chi Chen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cytokines are reported to be associated with the formation of prostate cancer. Our aim was to investigate whether C/T polymorphisms of the interleukin-2 (IL-2) gene and IL-2 receptor beta (IL-2RB) gene are associated with prostate cancer. We compared the frequency of the polymorphisms of the IL-2 gene and the IL-2RB gene between 96 patients with prostate cancer and 105 healthy male volunteers from the same area (age >60 years). They were followed for at least 5 years. There was a significant difference in distribution of the genotype of the IL-2 gene polymorphism between the prostate cancer group and the control group (P = 0.017). The distribution of the TT homozygote of the IL-2 gene was significantly higher in the cancer group (32.3%) than in the control group (16.2%). However, no significant statistical difference was found between the polymorphism of the IL-2 gene and prostate cancer in survival analysis during a 5-year follow up period (log rank test; P = 0.19). There was no significant difference in the distribution of the genotype of the IL-2RB gene polymorphism between controls and cancer patients (P = 0.388). This study suggests that the IL-2 gene may be associated with susceptibility to prostate cancer in the Taiwan population.

Original languageEnglish (US)
Pages (from-to)245-249
Number of pages5
JournalJournal of Clinical Laboratory Analysis
Volume20
Issue number6
DOIs
StatePublished - Dec 11 2006

Fingerprint

Polymorphism
Interleukin-2
Prostatic Neoplasms
Genes
Interleukin-2 Receptors
Interleukin-2 Receptor beta Subunit
Genotype
Control Groups
Homozygote
Survival Analysis
Taiwan
Neoplasms
Healthy Volunteers
Cytokines
Population

Keywords

  • Interleukin-2 gene (IL-2)
  • Interleukin-2 receptor gene (IL-2 R)
  • Prostate cancer
  • Single nucleotide polymorphisms (SNPs)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical
  • Microbiology (medical)

Cite this

IL-2 gene C/T polymorphism is associated with prostate cancer. / Wu, Hsi Chin; Chang, Chao Hsiang; Wan, Lei; Wu, Chao I.; Tsai, Fuu Jen; Chen, Wen Chi.

In: Journal of Clinical Laboratory Analysis, Vol. 20, No. 6, 11.12.2006, p. 245-249.

Research output: Contribution to journalArticle

Wu, Hsi Chin ; Chang, Chao Hsiang ; Wan, Lei ; Wu, Chao I. ; Tsai, Fuu Jen ; Chen, Wen Chi. / IL-2 gene C/T polymorphism is associated with prostate cancer. In: Journal of Clinical Laboratory Analysis. 2006 ; Vol. 20, No. 6. pp. 245-249.
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