TY - JOUR
T1 - Imaging and Screening of Hereditary Cancer Syndromes
AU - Katabathina, Venkata S.
AU - Menias, Christine O.
AU - Prasad, Srinivasa R.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/11
Y1 - 2017/11
N2 - There is a wide spectrum of mendelian disorders that predispose patients to an increased risk of benign as well as malignant tumors. Hereditary cancer syndromes are characterized by the early onset of diverse, frequently advanced malignancies in specific organ systems in multiple family members, posing significant challenges to diagnosis and management. A better understanding of the genetic abnormalities and pathophysiology that underlie these disorders has led to contemporary paradigms to screen, allowing early diagnosis, and has improved targeted therapies to aid in management. This article reviews select hereditary cancer syndromes with an emphasis on imaging-based screening and surveillance strategies.
AB - There is a wide spectrum of mendelian disorders that predispose patients to an increased risk of benign as well as malignant tumors. Hereditary cancer syndromes are characterized by the early onset of diverse, frequently advanced malignancies in specific organ systems in multiple family members, posing significant challenges to diagnosis and management. A better understanding of the genetic abnormalities and pathophysiology that underlie these disorders has led to contemporary paradigms to screen, allowing early diagnosis, and has improved targeted therapies to aid in management. This article reviews select hereditary cancer syndromes with an emphasis on imaging-based screening and surveillance strategies.
KW - Hereditary cancers
KW - Imaging findings
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=85032494861&partnerID=8YFLogxK
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U2 - 10.1016/j.rcl.2017.06.011
DO - 10.1016/j.rcl.2017.06.011
M3 - Review article
C2 - 28991567
AN - SCOPUS:85032494861
SN - 0033-8389
VL - 55
SP - 1293
EP - 1309
JO - Radiologic Clinics of North America
JF - Radiologic Clinics of North America
IS - 6
ER -