Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs

Chenchan Huang; Elizabeth M. Hecht; Erik V. Soloff; Hina Arif Tiwari; Priya R. Bhosale; Anil Dasayam; Samuel J. Galgano; Avinash Kambadakone; Naveen M. Kulkarni; Ott Le; Joy Liau; Lyndon Luk; Michael H. Rosenthal; Guillermo P. Sangster; Ajit H. Goenka

doi:10.2214/AJR.24.31151

Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs

Chenchan Huang
, Elizabeth M. Hecht
, Erik V. Soloff
, Hina Arif Tiwari
, Priya R. Bhosale
, Anil Dasayam
, Samuel J. Galgano
, Avinash Kambadakone
, Naveen M. Kulkarni
, Ott Le
, Joy Liau
, Lyndon Luk
, Michael H. Rosenthal
, Guillermo P. Sangster
, Ajit H. Goenka

Abdominal Imaging

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive cancers. It has a poor 5-year survival rate of 12%, partly because most cases are diagnosed at advanced stages, precluding curative surgical resection. Early-stage PDA has significantly better prognoses due to increased potential for curative interventions, making early detection of PDA critically important to improved patient outcomes. We examine current and evolving early detection concepts, screening strategies, diagnostic yields among high-risk individuals, controversies, and limitations of standard-of-care imaging.

Original language	English (US)
Article number	e2431151
Journal	American Journal of Roentgenology
Volume	223
Issue number	2
DOIs	https://doi.org/10.2214/AJR.24.31151
State	Published - Aug 2024

Keywords

early detection
high-risk individuals
new-onset diabetes
pancreatic cancer
screening
surveillance

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.2214/AJR.24.31151

Cite this

Huang, C., Hecht, E. M., Soloff, E. V., Tiwari, H. A., Bhosale, P. R., Dasayam, A., Galgano, S. J., Kambadakone, A., Kulkarni, N. M., Le, O., Liau, J., Luk, L., Rosenthal, M. H., Sangster, G. P., & Goenka, A. H. (2024). Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs. American Journal of Roentgenology, 223(2), Article e2431151. https://doi.org/10.2214/AJR.24.31151

Huang, C, Hecht, EM, Soloff, EV, Tiwari, HA, Bhosale, PR, Dasayam, A, Galgano, SJ, Kambadakone, A, Kulkarni, NM, Le, O, Liau, J, Luk, L, Rosenthal, MH, Sangster, GP & Goenka, AH 2024, 'Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs', American Journal of Roentgenology, vol. 223, no. 2, e2431151. https://doi.org/10.2214/AJR.24.31151

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abstract = "Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive cancers. It has a poor 5-year survival rate of 12\%, partly because most cases are diagnosed at advanced stages, precluding curative surgical resection. Early-stage PDA has significantly better prognoses due to increased potential for curative interventions, making early detection of PDA critically important to improved patient outcomes. We examine current and evolving early detection concepts, screening strategies, diagnostic yields among high-risk individuals, controversies, and limitations of standard-of-care imaging.",

keywords = "early detection, high-risk individuals, new-onset diabetes, pancreatic cancer, screening, surveillance",

author = "Chenchan Huang and Hecht, \{Elizabeth M.\} and Soloff, \{Erik V.\} and Tiwari, \{Hina Arif\} and Bhosale, \{Priya R.\} and Anil Dasayam and Galgano, \{Samuel J.\} and Avinash Kambadakone and Kulkarni, \{Naveen M.\} and Ott Le and Joy Liau and Lyndon Luk and Rosenthal, \{Michael H.\} and Sangster, \{Guillermo P.\} and Goenka, \{Ajit H.\}",

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doi = "10.2214/AJR.24.31151",

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AU - Hecht, Elizabeth M.

AU - Soloff, Erik V.

AU - Tiwari, Hina Arif

AU - Bhosale, Priya R.

AU - Dasayam, Anil

AU - Galgano, Samuel J.

AU - Kambadakone, Avinash

AU - Kulkarni, Naveen M.

AU - Le, Ott

AU - Liau, Joy

AU - Luk, Lyndon

AU - Rosenthal, Michael H.

AU - Sangster, Guillermo P.

AU - Goenka, Ajit H.

PY - 2024/8

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N2 - Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive cancers. It has a poor 5-year survival rate of 12%, partly because most cases are diagnosed at advanced stages, precluding curative surgical resection. Early-stage PDA has significantly better prognoses due to increased potential for curative interventions, making early detection of PDA critically important to improved patient outcomes. We examine current and evolving early detection concepts, screening strategies, diagnostic yields among high-risk individuals, controversies, and limitations of standard-of-care imaging.

AB - Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive cancers. It has a poor 5-year survival rate of 12%, partly because most cases are diagnosed at advanced stages, precluding curative surgical resection. Early-stage PDA has significantly better prognoses due to increased potential for curative interventions, making early detection of PDA critically important to improved patient outcomes. We examine current and evolving early detection concepts, screening strategies, diagnostic yields among high-risk individuals, controversies, and limitations of standard-of-care imaging.

KW - early detection

KW - high-risk individuals

KW - new-onset diabetes

KW - pancreatic cancer

KW - screening

KW - surveillance

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VL - 223

JO - American Journal of Roentgenology

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Imaging for Early Detection of Pancreatic Ductal Adenocarcinoma: Updates and Challenges in the Implementation of Screening and Surveillance Programs

Abstract

Keywords

ASJC Scopus subject areas

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