Imaging of colorectal carcinoma with technetium-99m radiolabeled Fab′ fragments

Donald A. Podoloff, Yehuda Z. Patt, Steven A. Curley, E. Edmond Kim, Vijaya A. Bhadkamkar, Ruth E. Smith

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In this phase III study, patients who had previously undergone surgery for colorectal cancer were studied using a technetium-99m (99mTc)-labeled anti CEA antibody (IMMU-4 [Immunomedics, Morris Plains, NJ] 1mg of protein) to evaluate recurrence. Total-body, planar, and single photon emission computed tomography (SPECT) images were performed within 6 hours of injection. Objectives were to evaluate the efficacy of the 99mTC-labeled anti-CEA antibody, to assess sensitivity and specificity of the agent in known lesions, and to detect occult disease. The impact of antibody study on subsequent surgery was also evaluated. The Fab' fragment has a molecular weight of 54,000 and is supplied as a lyophilized kit that can be instantaneously labeled with 20 to 30 mCi of [99mTc]pertechnetate. In 9 patients with known disease, planar spot imaging identified lesions in 7 (78% sensitivity), SPECT imaging detected lesions in 8 (88% sensitivity), and 1 patient did not have SPECT. In the group of 10 patients with occult (or equivolcal) disease, planar imaging sensitivity was 50%, and SPECT sensitivity was 100%. Analysis by site showed 14 of 24 lesions detected by planar imaging (58% sensitivity), and SPECT detected 24 of 24 lesions (100% sensitivity). Tumors as small as .5 cm were visualized in the 19 patients studied. The surgeon judged the antibody study to be impact neutral in 73% of the cases and helpful in 27% of the cases when antibody study altered the presurgical plan.

Original languageEnglish (US)
Pages (from-to)89-98
Number of pages10
JournalSeminars in Nuclear Medicine
Volume23
Issue number2
DOIs
StatePublished - Apr 1993

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Immunoglobulin Fab Fragments
Technetium
Single-Photon Emission-Computed Tomography
Colorectal Neoplasms
Antibodies
Anti-Idiotypic Antibodies
Sodium Pertechnetate Tc 99m
Molecular Weight
Recurrence
Sensitivity and Specificity
Injections
Neoplasms
Proteins

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Podoloff, D. A., Patt, Y. Z., Curley, S. A., Kim, E. E., Bhadkamkar, V. A., & Smith, R. E. (1993). Imaging of colorectal carcinoma with technetium-99m radiolabeled Fab′ fragments. Seminars in Nuclear Medicine, 23(2), 89-98. https://doi.org/10.1016/S0001-2998(05)80090-X

Imaging of colorectal carcinoma with technetium-99m radiolabeled Fab′ fragments. / Podoloff, Donald A.; Patt, Yehuda Z.; Curley, Steven A.; Kim, E. Edmond; Bhadkamkar, Vijaya A.; Smith, Ruth E.

In: Seminars in Nuclear Medicine, Vol. 23, No. 2, 04.1993, p. 89-98.

Research output: Contribution to journalArticle

Podoloff, DA, Patt, YZ, Curley, SA, Kim, EE, Bhadkamkar, VA & Smith, RE 1993, 'Imaging of colorectal carcinoma with technetium-99m radiolabeled Fab′ fragments', Seminars in Nuclear Medicine, vol. 23, no. 2, pp. 89-98. https://doi.org/10.1016/S0001-2998(05)80090-X
Podoloff, Donald A. ; Patt, Yehuda Z. ; Curley, Steven A. ; Kim, E. Edmond ; Bhadkamkar, Vijaya A. ; Smith, Ruth E. / Imaging of colorectal carcinoma with technetium-99m radiolabeled Fab′ fragments. In: Seminars in Nuclear Medicine. 1993 ; Vol. 23, No. 2. pp. 89-98.
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