TY - JOUR
T1 - Imaging Surveillance of Limited-stage Classic Hodgkin Lymphoma Patients After PET–CT-documented First Remission
AU - Glober, Gordon
AU - Gunther, Jillian
AU - Fang, Penny
AU - Milgrom, Sarah
AU - Korivi, Brinda Rao
AU - Jensen, Corey T.
AU - Wagner-Bartak, Nicolaus A.
AU - Ahmed, Sairah
AU - Lee, Hun Ju
AU - Nair, Ranjit
AU - Steiner, Raphael
AU - Parmar, Simrit
AU - Iyer, Swaminathan
AU - Westin, Jason
AU - Fayad, Luis
AU - Rodriguez, M. Alma
AU - Neelapu, Sattva
AU - Nastoupil, Loretta
AU - Flowers, Christopher R.
AU - Dabaja, Bouthaina S.
AU - Pinnix, Chelsea C.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/8
Y1 - 2020/8
N2 - Introduction: Early stage Hodgkin lymphoma (ESHL) is highly curable; however, 10% to 15% of patients experience relapse. We examined the utilization of follow-up imaging for patients with ESHL who achieved a metabolic complete response after upfront therapy. Materials and Methods: The records of adult patients treated at a single institution between 2003 and 2014 were reviewed. Positron emission tomography-computed tomography (PET-CT) and CT scan frequency was quantified during the 2 years following treatment and subsequent visits beyond 2 years. Results: The study cohort contained 179 patients. The median age was 31 years; bulky disease was present in 30%. ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) or AVD (doxorubicin, vinblastine, and dacarbazine) was given in 97%; 75% received radiation therapy. At a median follow-up of 6.9 years, the 5-year progression-free and overall survival rates were 93.7% and 98.1%, respectively. Relapse occurred in 5% (n = 9) of patients at a median of 9.1 months (range, 4.6-27.2 months) from therapy. Two patients presented with symptoms prompting imaging in follow-up. Within 2 years after therapy, 376 PET-CT scans and 3325 CT scans were performed, yielding an average of 2.1 PET-CTs and 18.6 CTs per patient. Of the initial 179 patients, 113 had follow-up conducted beyond 2 years post-therapy; an average of 2.7 PET-CTs and 33.2 CTs were performed. In the 2-year post-therapy period, 463 scans were performed per relapse detected. Conclusion: In this cohort of patients with ESHL who responded completely to frontline therapy, the relapse rate was low. Routine imaging surveillance lacks clinical benefit in this patient population. Surveillance imaging among patients with Hodgkin lymphoma is controversial. We examined the imaging surveillance strategy of patients with early stage Hodgkin lymphoma who responded completely to frontline therapy at a single institution. The rate of relapse was low, suggesting no benefit for follow up positron emission tomography-computed tomography and computed tomography imaging studies in this patient population.
AB - Introduction: Early stage Hodgkin lymphoma (ESHL) is highly curable; however, 10% to 15% of patients experience relapse. We examined the utilization of follow-up imaging for patients with ESHL who achieved a metabolic complete response after upfront therapy. Materials and Methods: The records of adult patients treated at a single institution between 2003 and 2014 were reviewed. Positron emission tomography-computed tomography (PET-CT) and CT scan frequency was quantified during the 2 years following treatment and subsequent visits beyond 2 years. Results: The study cohort contained 179 patients. The median age was 31 years; bulky disease was present in 30%. ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) or AVD (doxorubicin, vinblastine, and dacarbazine) was given in 97%; 75% received radiation therapy. At a median follow-up of 6.9 years, the 5-year progression-free and overall survival rates were 93.7% and 98.1%, respectively. Relapse occurred in 5% (n = 9) of patients at a median of 9.1 months (range, 4.6-27.2 months) from therapy. Two patients presented with symptoms prompting imaging in follow-up. Within 2 years after therapy, 376 PET-CT scans and 3325 CT scans were performed, yielding an average of 2.1 PET-CTs and 18.6 CTs per patient. Of the initial 179 patients, 113 had follow-up conducted beyond 2 years post-therapy; an average of 2.7 PET-CTs and 33.2 CTs were performed. In the 2-year post-therapy period, 463 scans were performed per relapse detected. Conclusion: In this cohort of patients with ESHL who responded completely to frontline therapy, the relapse rate was low. Routine imaging surveillance lacks clinical benefit in this patient population. Surveillance imaging among patients with Hodgkin lymphoma is controversial. We examined the imaging surveillance strategy of patients with early stage Hodgkin lymphoma who responded completely to frontline therapy at a single institution. The rate of relapse was low, suggesting no benefit for follow up positron emission tomography-computed tomography and computed tomography imaging studies in this patient population.
KW - CT
KW - Early stage Hodgkin lymphoma
KW - Follow up
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U2 - 10.1016/j.clml.2020.02.008
DO - 10.1016/j.clml.2020.02.008
M3 - Article
C2 - 32291233
AN - SCOPUS:85083046082
SN - 2152-2650
VL - 20
SP - 533
EP - 541
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 8
ER -