Immune Checkpoint Inhibitor Therapy as an Eye-Preserving Treatment for Locally Advanced Conjunctival Melanoma

Bennett Yau Bun Hong, Joshua R. Ford, Isabella C. Glitza, Carlos A. Torres Cabala, Michael Tetzlaff, Victor G. Prieto, Richard Parker, Claire Daniel, Bita Esmaeli

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The authors present 2 patients with locally advanced conjunctival melanoma for whom definitive surgery would mean an orbital exenteration with its associated inherent total visual loss and major facial disfigurement. Instead both patients were treated with immune checkpoint inhibitor therapy. In 1 patient neoadjuvant pembrolizumab was used for approximately 12 months and the patient experienced near-total clinical resolution of the conjunctival melanoma. Multiple surgical biopsies of very small residual pigmentation showed pigmented macrophages and a complete pathologic response. In the second patient who presented with a locally advanced and metastatic conjunctival melanoma, significant shrinkage of conjunctival mass was observed after treatment with a combination of ipilimumab and nivolumab for 5 months, and this allowed preservation of the eye and ocular function.

Original languageEnglish (US)
Pages (from-to)E9-E13
JournalOphthalmic plastic and reconstructive surgery
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2021

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

MD Anderson CCSG core facilities

  • Clinical Trials Office
  • Research Histology Core Lab
  • Tissue Biospecimen and Pathology Resource

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