@inbook{12b56d0f63ef4d7fac53b50ece3f5112,
title = "Immune checkpoint inhibitors-induced colitis",
abstract = "Immune checkpoint inhibitors (ICIs) have shown significant benefit in cancer patients, but are associated with immune-related adverse events (irAEs), that can affect the gastrointestinal tract resulting in diarrhea and colitis. IrAEs range from mild self-limiting to severe life-threatening disease, which potentially limit the use of these medications. Diagnosis of ICI-induced colitis is based on clinical symptoms, physical examination, stool tests, endoscopic evaluation, and/or imaging. Current management strategy is mainly anti-diarrheal agents for mild symptoms, and immunosuppressants (e.g., corticosteroids, and infliximab or vedolizumab) for more severe cases.",
keywords = "Colitis, Corticosteroids, Diarrhea, Immune checkpoint inhibitors, Immunotherapy, Infliximab, Steroids",
author = "Yun Tian and Hamzah Abu-Sbeih and Yinghong Wang",
note = "Publisher Copyright: {\textcopyright} Springer Nature Switzerland AG 2018.",
year = "2018",
doi = "10.1007/978-3-030-02505-2_7",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "151--157",
booktitle = "Advances in Experimental Medicine and Biology",
}