Immune evasion mechanisms of human papillomavirus: An update

Alina Steinbach, Angelika B. Riemer

    Research output: Contribution to journalReview article

    24 Scopus citations

    Abstract

    Human papillomavirus (HPV) is the most frequently sexually transmitted agent in the world. It can cause cervical and other anogenital malignancies, and oropharyngeal cancer. HPV has the unique ability to persist in the host's epithelium for a long time—longer than most viruses do—which is necessary to complete its replication cycle. To this end, HPV has developed a variety of immune evasion mechanisms, which unfortunately also favor the progression of the disease from infection to chronic dysplasia and eventually to cancer. This article summarizes the current knowledge about HPV immune evasion strategies. A special emphasis lies in HPV-mediated changes of the antigen processing machinery, which is generating epitopes for T cells and contributes to the detectability of infected cells.

    Original languageEnglish (US)
    Pages (from-to)224-229
    Number of pages6
    JournalInternational Journal of Cancer
    Volume142
    Issue number2
    DOIs
    StatePublished - Jan 15 2018

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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