Immune evasion mechanisms of human papillomavirus: An update

Alina Steinbach, Angelika B. Riemer

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Human papillomavirus (HPV) is the most frequently sexually transmitted agent in the world. It can cause cervical and other anogenital malignancies, and oropharyngeal cancer. HPV has the unique ability to persist in the host's epithelium for a long time—longer than most viruses do—which is necessary to complete its replication cycle. To this end, HPV has developed a variety of immune evasion mechanisms, which unfortunately also favor the progression of the disease from infection to chronic dysplasia and eventually to cancer. This article summarizes the current knowledge about HPV immune evasion strategies. A special emphasis lies in HPV-mediated changes of the antigen processing machinery, which is generating epitopes for T cells and contributes to the detectability of infected cells.

Original languageEnglish (US)
Pages (from-to)224-229
Number of pages6
JournalInternational Journal of Cancer
Volume142
Issue number2
DOIs
StatePublished - Jan 15 2018

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Immune Evasion
Oropharyngeal Neoplasms
T-Lymphocyte Epitopes
Antigen Presentation
Disease Progression
Neoplasms
Epithelium
Viruses
Infection

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Immune evasion mechanisms of human papillomavirus : An update. / Steinbach, Alina; Riemer, Angelika B.

In: International Journal of Cancer, Vol. 142, No. 2, 15.01.2018, p. 224-229.

Research output: Contribution to journalReview article

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