Immune suppression and skin cancer development: Regulation by NKT cells

Angus M. Moodycliffe; Dat Nghiem; Gavin Clydesdale; Stephen E. Ullrich

doi:10.1038/82782

Immune suppression and skin cancer development: Regulation by NKT cells

Angus M. Moodycliffe, Dat Nghiem, Gavin Clydesdale, Stephen E. Ullrich

Immunology

Research output: Contribution to journal › Article › peer-review

290 Scopus citations

Abstract

Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.

Original language	English (US)
Pages (from-to)	521-525
Number of pages	5
Journal	Nature Immunology
Volume	1
Issue number	6
DOIs	https://doi.org/10.1038/82782
State	Published - Dec 2000

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/82782

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title = "Immune suppression and skin cancer development: Regulation by NKT cells",

abstract = "Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.",

author = "Moodycliffe, {Angus M.} and Dat Nghiem and Gavin Clydesdale and Ullrich, {Stephen E.}",

note = "Funding Information: Acknowledgments We thank H.Ananthaswamy and L. Owen-Schaub for critically reviewing this manuscript and L.Van Kaer for providing inbred CD1-deficient and WT mice. Supported by grants from the NIH (CA75575 and ES07327).The animal facilities at UT MDACC are supported in part by a NCI Core Grant (CA16672).",

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AU - Moodycliffe, Angus M.

AU - Nghiem, Dat

AU - Clydesdale, Gavin

AU - Ullrich, Stephen E.

N1 - Funding Information: Acknowledgments We thank H.Ananthaswamy and L. Owen-Schaub for critically reviewing this manuscript and L.Van Kaer for providing inbred CD1-deficient and WT mice. Supported by grants from the NIH (CA75575 and ES07327).The animal facilities at UT MDACC are supported in part by a NCI Core Grant (CA16672).

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N2 - Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.

AB - Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.

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Immune suppression and skin cancer development: Regulation by NKT cells

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