TY - JOUR
T1 - Immunologic correlates of pathologic complete response to preoperative immunotherapy in hepatocellular carcinoma
AU - Kaseb, Ahmed Omar
AU - Vence, Luis
AU - Blando, Jorge
AU - Yadav, Shalini S.
AU - Ikoma, Naruhiko
AU - Pestana, Roberto Carmagnani
AU - Vauthey, Jean Nicolas
AU - Allison, James P.
AU - Sharma, Padmanee
N1 - Funding Information:
This work was funded by Bristol-Myers Squibb.
Publisher Copyright:
© 2019 American Association for Cancer Research.
PY - 2019
Y1 - 2019
N2 - In hepatocellular carcinoma (HCC), surgical resection is associated with high recurrence rate, and no effective adjuvant therapy currently exists. We initiated a pilot randomized trial of perioperative immunotherapy with nivolumab and ipilimumab for resectable HCC. Here, we provide an illustrative report of a case that achieved a complete response and report immunologic correlates of this complete pathologic response to perioperative immunotherapy. Clinical response was correlated with an increase in CD8þ T-cell infiltration, with an increase in two effector T-cell clusters. This study is ongoing, and the final results may contribute to a paradigm shift in the perioperative treatment of HCC, leading to the incorporation of immunotherapy in the curative setting.
AB - In hepatocellular carcinoma (HCC), surgical resection is associated with high recurrence rate, and no effective adjuvant therapy currently exists. We initiated a pilot randomized trial of perioperative immunotherapy with nivolumab and ipilimumab for resectable HCC. Here, we provide an illustrative report of a case that achieved a complete response and report immunologic correlates of this complete pathologic response to perioperative immunotherapy. Clinical response was correlated with an increase in CD8þ T-cell infiltration, with an increase in two effector T-cell clusters. This study is ongoing, and the final results may contribute to a paradigm shift in the perioperative treatment of HCC, leading to the incorporation of immunotherapy in the curative setting.
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U2 - 10.1158/2326-6066.CIR-18-0605
DO - 10.1158/2326-6066.CIR-18-0605
M3 - Article
C2 - 31289040
AN - SCOPUS:85071783035
SN - 2326-6066
VL - 7
SP - 1390
EP - 1395
JO - Cancer Immunology Research
JF - Cancer Immunology Research
IS - 9
ER -