Immunologic defects in young male patients with hepatitis-associated aplastic anemia

K. A. Foon, R. T. Mitsuyasu, R. W. Schroff, R. E. McIntyre, Richard E Champlin, R. P. Gale

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Extensive immunologic studies were done in 97 patients with severe aplastic anemia between 1973 and 1979. Sixteen young male patients with hepatitis-associated aplastic anemia appeared to constitute a unique subset. Compared with most patients with aplastic anemia from other causes, these 16 patients had significant reductions in the mean values of circulating T lymphocytes, serum IgG and IgM, mitogen reactivity, and decreased cutaneous hypersensitivity. The ratio of peripheral blood helper to suppressor T lymphocytes identified by monoclonal antibodies was within normal limits in 3 patients studied with hepatitis-associated aplastic anemia. Interestingly, the ratio was low (<1) in 3 of 7 patients studied with aplastic anemia from other causes, although the mean for these 7 patients was normal. These data suggest that patients in this subset with hepatitis-associated severe aplastic anemia have a severe immunodeficiency. Whether this immunodeficiency is the cause or result of the hepatitis or aplastic anemia, or both, is unknown.

Original languageEnglish (US)
Pages (from-to)657-662
Number of pages6
JournalAnnals of Internal Medicine
Volume100
Issue number5
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Internal Medicine

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