Immunomodulation therapy with lenalidomide in follicular, transformed and diffuse large B cell lymphoma: Current data on safety and efficacy

Madhav Desai; Kate J. Newberry; Jorge Romaguera; Liang Zhang; Zhishuo Ou; Michael Wang

doi:10.1186/1756-8722-6-55

Immunomodulation therapy with lenalidomide in follicular, transformed and diffuse large B cell lymphoma: Current data on safety and efficacy

Madhav Desai, Kate J. Newberry, Jorge Romaguera, Liang Zhang, Zhishuo Ou, Michael Wang

Lymphoma-Myeloma

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Lenalidomide is an immunomodulatory agent which has been approved for multiple myeloma. Lenalidomide is also effective in and tolerated well by patients with follicular lymphoma, diffuse large B-cell lymphoma, and transformed large cell lymphoma. This review summarizes the results of current preclinical and clinical studies of lenalidomide, alone or in combination with the monoclonal antibody rituximab, as a therapeutic option for these three lymphoma types. This review will serve as a tool guiding future clinical investigations to improve survival rates for these three lymphomas.

Original language	English (US)
Article number	55
Journal	Journal of Hematology and Oncology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1186/1756-8722-6-55
State	Published - 2013

Keywords

B-cell
Immunomodulatory
Lenalidomide
Lymphoma

ASJC Scopus subject areas

Molecular Biology
Hematology
Oncology
Cancer Research

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10.1186/1756-8722-6-55

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abstract = "Lenalidomide is an immunomodulatory agent which has been approved for multiple myeloma. Lenalidomide is also effective in and tolerated well by patients with follicular lymphoma, diffuse large B-cell lymphoma, and transformed large cell lymphoma. This review summarizes the results of current preclinical and clinical studies of lenalidomide, alone or in combination with the monoclonal antibody rituximab, as a therapeutic option for these three lymphoma types. This review will serve as a tool guiding future clinical investigations to improve survival rates for these three lymphomas.",

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T2 - Current data on safety and efficacy

AU - Desai, Madhav

AU - Newberry, Kate J.

AU - Romaguera, Jorge

AU - Zhang, Liang

AU - Ou, Zhishuo

AU - Wang, Michael

PY - 2013

Y1 - 2013

N2 - Lenalidomide is an immunomodulatory agent which has been approved for multiple myeloma. Lenalidomide is also effective in and tolerated well by patients with follicular lymphoma, diffuse large B-cell lymphoma, and transformed large cell lymphoma. This review summarizes the results of current preclinical and clinical studies of lenalidomide, alone or in combination with the monoclonal antibody rituximab, as a therapeutic option for these three lymphoma types. This review will serve as a tool guiding future clinical investigations to improve survival rates for these three lymphomas.

AB - Lenalidomide is an immunomodulatory agent which has been approved for multiple myeloma. Lenalidomide is also effective in and tolerated well by patients with follicular lymphoma, diffuse large B-cell lymphoma, and transformed large cell lymphoma. This review summarizes the results of current preclinical and clinical studies of lenalidomide, alone or in combination with the monoclonal antibody rituximab, as a therapeutic option for these three lymphoma types. This review will serve as a tool guiding future clinical investigations to improve survival rates for these three lymphomas.

KW - B-cell

KW - Immunomodulatory

KW - Lenalidomide

KW - Lymphoma

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Immunomodulation therapy with lenalidomide in follicular, transformed and diffuse large B cell lymphoma: Current data on safety and efficacy

Abstract

Keywords

ASJC Scopus subject areas

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