Immunomodulatory Methods

Cynthia Kassab, Brittany Parker Kerrigan, Hillary Caruso, Sanaalarab Al Enazy, Amy B. Heimberger

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Immunotherapy for treatment of diseases of the central nervous system (CNS) has garnered significant interest, especially since the discovery of the lymphatic circulation and immune cell trafficking. Multiple immunomodulatory methods are under development for neurodegenerative and inflammatory diseases of the CNS, but the most active area of study is focused on brain tumors. In this chapter, we provide an overview of immunotherapy strategies while providing a critical assessment of those that hold the most promise. Notably, although most immunotherapy clinical trials have focused on glioblastoma, recent data suggest that other types of CNS malignancies and disorders may be amenable to immune therapeutic strategies, several of which demonstrate promise. However, further investigation is required to overcome the heterogeneity of these tumors and their continuous shift to resistance mechanisms.

Original languageEnglish (US)
Title of host publicationNervous System Drug Delivery
Subtitle of host publicationPrinciples and Practice
PublisherElsevier
Pages297-334
Number of pages38
ISBN (Electronic)9780128139981
ISBN (Print)9780128139974
DOIs
StatePublished - Jun 25 2019

Keywords

  • Active immunotherapy
  • Alzheimer disease
  • Antibodies
  • Cell therapies
  • Cytokines
  • Glioma
  • Headaches
  • Immune biologics
  • Immune checkpoint inhibitors
  • Immunomodulation
  • Multiple sclerosis
  • Virotherapy

ASJC Scopus subject areas

  • Medicine(all)

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