IMMUNOPROPHYLAXIS WITH BCG OF EXPERIMENTAL ECHINOCOCCUS MULTILOCULARIS INFECTIONS

J. M. Reuben; C. E. Tanner

doi:10.1111/j.1751-0813.1979.tb15243.x

IMMUNOPROPHYLAXIS WITH BCG OF EXPERIMENTAL ECHINOCOCCUS MULTILOCULARIS INFECTIONS

J. M. Reuben, C. E. Tanner

Hematopathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

SUMMARY: Infection by the metacestodes of Echinococcus multilocularis is an example of the biological paradox of a proliferating parasite in an immunologically‐competent host. There is evidence that infection with these organisms is regulated. A study of this regulation has shown that hydatid cysts can be effectively treated with complement and that the cellular defence mechanisms of the host can be non‐specifically activated with BCG; treatment with BCG presents an effective prophylactic measure against infection with E. multilocularis. The mechanisms by which parasite infections are regulated can furnish clues to possible prophylactic and therapeutic strategies.

Original language	English (US)
Pages (from-to)	105-108
Number of pages	4
Journal	Australian Veterinary Journal
Volume	55
Issue number	3
DOIs	https://doi.org/10.1111/j.1751-0813.1979.tb15243.x
State	Published - Mar 1979

ASJC Scopus subject areas

General Veterinary

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AB - SUMMARY: Infection by the metacestodes of Echinococcus multilocularis is an example of the biological paradox of a proliferating parasite in an immunologically‐competent host. There is evidence that infection with these organisms is regulated. A study of this regulation has shown that hydatid cysts can be effectively treated with complement and that the cellular defence mechanisms of the host can be non‐specifically activated with BCG; treatment with BCG presents an effective prophylactic measure against infection with E. multilocularis. The mechanisms by which parasite infections are regulated can furnish clues to possible prophylactic and therapeutic strategies.

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IMMUNOPROPHYLAXIS WITH BCG OF EXPERIMENTAL ECHINOCOCCUS MULTILOCULARIS INFECTIONS

Abstract

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