Immunosuppression Routed Via the Kynurenine Pathway: A Biochemical and Pathophysiologic Approach

Álvaro González, Nerea Varo, Estibaliz Alegre, Angel Díaz, Ignacio Melero

Research output: Chapter in Book/Report/Conference proceedingChapter

36 Scopus citations

Abstract

In the past years, it has been shown that kynurenines pathway is a regulator of both the innate and the adaptive immune responses. Particularly, the initial enzyme of this pathway, indoleamine 2,3-dioxygenase (IDO), is implicated in maintaining tolerance during pregnancy, and also can be expressed in tumors to avoid the immune attack. In this chapter, we will describe how the kynurenine pathway affects the immune system with important implications both in physiology and in pathology. The incorrect activation or blockade suppressive properties of the kynurenine pathway are also implicated in a number of other diseases such as AIDS or autoimmune diseases.

Original languageEnglish (US)
Title of host publicationAdvances in Clinical Chemistry
EditorsGregory S. Makowski
Pages155-197
Number of pages43
EditionSUPPL.: COMPLETE
DOIs
StatePublished - 2008

Publication series

NameAdvances in Clinical Chemistry
NumberSUPPL.: COMPLETE
Volume45
ISSN (Print)0065-2423

ASJC Scopus subject areas

  • General Chemistry
  • Clinical Biochemistry

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