Abstract
Background: Persistent pain and opioid use can be devastating after cytoreductive surgery (CRS) and hyperthermic intraoperative chemotherapy (HIPEC). Methods: We conducted a retrospective study to investigate the impact of ketamine use on postoperative complications and persistent and chronic pain after CRS-HIPEC. Results: Ketamine reduced perioperative opioid use before and after implementation of recovery after surgery programs. Ketamine did not impact the formation of persistent and chronic pain formation and long-term opioid use. Postoperative complications and postoperative reoperations were independent predictors of persistent pain. Interestingly, the risk of having a complication was increased by 1% for every doubling in opioids used intraoperatively. Conclusion: Ketamine use reduces perioperative opioid consumption in patients undergoing CRS-HIPEC, but it is not associated with improvements in long-term opioid use and chronic pain.
Original language | English (US) |
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Pages (from-to) | 2433-2439 |
Number of pages | 7 |
Journal | Journal of Pain Research |
Volume | 14 |
DOIs | |
State | Published - 2021 |
Keywords
- Cancer
- Chronic pain
- Cytoreductive surgery
- Ketamine
- Neoplasm
- Opioids
- Surgery
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
MD Anderson CCSG core facilities
- Biostatistics Resource Group