Impact of obesity on airway and lung parenchyma remodeling in experimental chronic allergic asthma

Simone A. Saraiva, Adriana L. Silva, Débora G. Xisto, Soraia C. Abreu, Johnatas D. Silva, Pedro L. Silva, Tatiana P.F. Teixeira, Edwin R. Parra, Ana Laura N. Carvalho, Raquel Annoni, Thais Mauad, Vera L. Capelozzi, Patricia M.R. Silva, Marco A. Martins, Patricia R.M. Rocco

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The impact of obesity on the inflammatory process has been described in asthma, however little is known about the influence of diet-induced obesity on lung remodeling. For this purpose, 56 recently weaned A/J mice were randomly divided into 2 groups. In the C group, mice were fed a standard chow diet, while OB animals received isocaloric high-fat diet to reach 1.5 of the mean body weight of C. After 12 weeks, each group was further randomized to be sensitized and challenged with ovalbumin (OVA) or saline. Twenty-four hours after the last challenge, collagen fiber content in airways and lung parenchyma, the volume proportion of smooth muscle-specific actin in alveolar ducts and terminal bronchiole, and the number of eosinophils in bronchoalveolar lavage fluid were higher in OB-OVA than C-OVA. In conclusion, diet-induced obesity enhanced lung remodeling resulting in higher airway responsiveness in the present experimental chronic allergic asthma.

Original languageEnglish (US)
Pages (from-to)141-148
Number of pages8
JournalRespiratory Physiology and Neurobiology
Volume177
Issue number2
DOIs
StatePublished - Jul 31 2011
Externally publishedYes

Keywords

  • Airway
  • Asthma
  • Collagen fiber
  • Electron microscopy
  • Eosinophil

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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