TY - JOUR
T1 - Impact of perioperative pain management on cancer recurrence
T2 - An ASRA/ESRA special article
AU - Missair, Andres
AU - Cata, Juan Pablo
AU - Votta-Velis, Gina
AU - Johnson, Mark
AU - Borgeat, Alain
AU - Tiouririne, Mohammed
AU - Gottumukkala, Vijay
AU - Buggy, Donal
AU - Vallejo, Ricardo
AU - Marrero, Esther Benedetti De
AU - Sessler, Dan
AU - Huntoon, Marc A.
AU - Andres, Jose De
AU - Casasola, Oscar De Leon
N1 - Publisher Copyright:
© 2019 American Society of Regional Anesthesia & Pain Medicine.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Cancer causes considerable suffering and 80% of advanced cancer patients experience moderate to severe pain. Surgical tumor excision remains a cornerstone of primary cancer treatment, but is also recognized as one of the greatest risk factors for metastatic spread. The perioperative period, characterized by the surgical stress response, pharmacologic-induced angiogenesis, and immunomodulation results in a physiologic environment that supports tumor spread and distant reimplantation.In the perioperative period, anesthesiologists may have a brief and uniquewindow of opportunity to modulate the unwanted consequences of the stressresponse on the immune system and minimize residual disease. This reviewdiscusses the current research on analgesic therapies and their impact ondisease progression, followed by an evidence-based evaluation of perioperativepain interventions and medications.
AB - Cancer causes considerable suffering and 80% of advanced cancer patients experience moderate to severe pain. Surgical tumor excision remains a cornerstone of primary cancer treatment, but is also recognized as one of the greatest risk factors for metastatic spread. The perioperative period, characterized by the surgical stress response, pharmacologic-induced angiogenesis, and immunomodulation results in a physiologic environment that supports tumor spread and distant reimplantation.In the perioperative period, anesthesiologists may have a brief and uniquewindow of opportunity to modulate the unwanted consequences of the stressresponse on the immune system and minimize residual disease. This reviewdiscusses the current research on analgesic therapies and their impact ondisease progression, followed by an evidence-based evaluation of perioperativepain interventions and medications.
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U2 - 10.1136/rapm-2018-000001
DO - 10.1136/rapm-2018-000001
M3 - Article
C2 - 30640648
AN - SCOPUS:85060060845
SN - 1098-7339
VL - 44
SP - 13
EP - 28
JO - Regional anesthesia and pain medicine
JF - Regional anesthesia and pain medicine
IS - 1
ER -