Impact of renal vein invasion and fat invasion in pT3a renal cell carcinoma

Walter Henriques Da Costa, Ravendra R. Moniz, Isabela Werneck Da Cunha, Francisco Paulo Fonseca, Gustavo Cardoso Guimaraes, Stênio De Cássio Zequi

    Research output: Contribution to journalReview article

    23 Scopus citations

    Abstract

    OBJECTIVE To evaluate the prognostic impact of tumor fat invasion (FI) and renal vein invasion (RVI) in patients with T3a renal cell carcinoma. PATIENTS AND METHODS In total, 220 consecutive patients treated for renal cell carcinoma between 1992 and 2009 were analyzed. T3a stage cases were selected. A single pathologist reviewed all cases. RESULTS The present study cohort included 46 patients with mean follow-up of 28.6 months, of whom 17 (36.9%) died from disease. Patients were initially divided into three groups including 24 (52.1%) of FI only, 11 (23.9%) of RVI only and 11 (23.9%) of both FI and RVI. In univariate analysis, no significant differences in disease-specific survival (DSS) were noted between FI only and RVI only groups (P= 0.91). DSS was significantly worse in the FI + RVI group compared to the other groups (P= 0.02). When grouped into FI or RVI vs FI + RVI, DSS remained significantly lower in the group containing the parameters concurrently (P= 0.009). Progression-free survival also was significantly lower in FI + RVI group (P= 0.01). Metastasis, positive lymph nodes and the presence of FI + RVI remained as isolated predictors of survival. Patients with FI + RVI presented a 2.6-fold increase in risk of death from cancer and a 2.5-fold increase in risk of disease progression (P= 0.04) compared to those with either of them alone. CONCLUSION The isolated or concomitant presence of FI and RVI may be used as one of the criteria for staging in the next edition of the Tumour-Node-Metastasis classification because they have significantly different outcomes.

    Original languageEnglish (US)
    Pages (from-to)544-548
    Number of pages5
    JournalBJU International
    Volume109
    Issue number4
    DOIs
    StatePublished - Feb 1 2012

    Keywords

    • kidney
    • oncology
    • prognosis
    • renal carcinoma

    ASJC Scopus subject areas

    • Urology

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    Da Costa, W. H., Moniz, R. R., Da Cunha, I. W., Fonseca, F. P., Guimaraes, G. C., & De Cássio Zequi, S. (2012). Impact of renal vein invasion and fat invasion in pT3a renal cell carcinoma. BJU International, 109(4), 544-548. https://doi.org/10.1111/j.1464-410X.2011.10366.x