Impact of statin use on outcomes in triple negative breast cancer

Simona F. Shaitelman, Michael C. Stauder, Pamela Allen, Sangeetha Reddy, Susan Lakoski, Bradley Atkinson, Jay P Reddy, Diana Amaya, William Guerra, Naoto T Ueno, Abigail Suzanne Caudle, Welela Tereffe, Wendy Woodward

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Purpose: We sought to investigate if the use of HMG Co-A reductase inhibitors (statins) has an impact on outcomes among patients with triple negative breast cancer (TNBC). Methods: We reviewed the cases of women with invasive, non-metastatic TNBC, diagnosed 1997-2012. Clinical outcomes were compared based on statin use (defined as ever use during treatment vs. never use). We identified a subset of women for whom a 5-value lipid panel (5VLP) was available, including total cholesterol, low density lipoprotein, high density lipoprotein, very low density lipoprotein, and triglycerides. The Kaplan-Meier method was used to estimate median overall survival (OS), distant metastases-free survival (DMFS), and local-regional recurrence-free survival (LRRFS). A Cox proportional hazards regression model was used to test the statistical significance of prognostic factors. Results: 869 women were identified who met inclusion criteria, with a median follow-up time of 75.1 months (range 2.4-228.9 months). 293 (33.7%) patients used statins and 368 (42.3%) had a 5VLP. OS, DMFS, and LRRFS were not significant based on statin use or type. Controlling for the 5VLP values, on multivariable analysis, statin use was significantly associated with OS (HR 0.10, 95% CI 0.01-0.76), but not with DMFS (HR 0.14, 95% CI 0.01-1.40) nor LRRFS (HR 0.10 95% CI 0.00-3.51). Conclusions: Statin use among patients with TNBC is not associated with improved OS, although it may have a benefit for a subset of patients. Prospective assessment would be valuable to better assess the potential complex correlation between clinical outcome, lipid levels, and statin use.

Original languageEnglish (US)
Pages (from-to)2026-2032
Number of pages7
JournalJournal of Cancer
Volume8
Issue number11
DOIs
StatePublished - 2017

Keywords

  • Breast cancer
  • Cholesterol
  • Statin
  • Triple negative

ASJC Scopus subject areas

  • Oncology

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