Impact of tumor dimensions and lymph node density on the survival of patients with hypopharyngeal squamous cell carcinoma

Lu Lu Ye, Jia Rao, Xing Wen Fan, Qing Hai Ji, Chao Su Hu, Hong Mei Ying

Research output: Contribution to journalArticle

Abstract

Purpose: To analyze the potential variables affecting the survival of patients undergoing primary surgery for hypopharyngeal squamous cell carcinoma. Patients and methods: Between August 2007 and December 2016, 93 patients with primary hypopharyngeal squamous cell carcinomas undergoing radical surgery at Fudan University Shanghai Cancer Center were reviewed. The clinicopathological features were analyzed retrospectively. The optimal cutoff values were determined based on the receiver operating characteristic curve analysis. Pearson correlation coefficients were used to assess the correlations between variables. The Kaplan–Meier and Cox proportional hazard methods were used to evaluate the impact of variables on overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Results: Cox multivariate analysis revealed that a depth of invasion (DOI) ≥ 4.3 mm was correlated with inferior OS (P=0.045), DSS (P=0.046), and DFS (P=0.046). A primary tumor volume (PTV) ≥0.36 mL was related to poor OS (P=0.018), DSS (P=0.026), and DFS (P=0.036). A lymph node density (LND) ≥0.07 was also associated with worse OS (P=0.014) and DSS (P=0.045). Moreover, additional prognostic value was observed in the combined use of PTV and LND. Conclusion: The DOI, PTV, and LND obtained from the surgical specimens could provide additional valuable information for prognostic stratification and allowed the more appropriate selection of suitable candidates for more aggressive adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)4679-4688
Number of pages10
JournalCancer Management and Research
Volume10
DOIs
StatePublished - Jan 1 2018

Fingerprint

Squamous Cell Carcinoma
Lymph Nodes
Survival
Neoplasms
Tumor Burden
Disease-Free Survival
ROC Curve
Multivariate Analysis

Keywords

  • Depth of invasion
  • Hypopharynx
  • Lymph node density
  • Primary tumor volume
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Oncology

Cite this

Impact of tumor dimensions and lymph node density on the survival of patients with hypopharyngeal squamous cell carcinoma. / Ye, Lu Lu; Rao, Jia; Fan, Xing Wen; Ji, Qing Hai; Hu, Chao Su; Ying, Hong Mei.

In: Cancer Management and Research, Vol. 10, 01.01.2018, p. 4679-4688.

Research output: Contribution to journalArticle

@article{d8949bf399b04976a715e034bc9f763f,
title = "Impact of tumor dimensions and lymph node density on the survival of patients with hypopharyngeal squamous cell carcinoma",
abstract = "Purpose: To analyze the potential variables affecting the survival of patients undergoing primary surgery for hypopharyngeal squamous cell carcinoma. Patients and methods: Between August 2007 and December 2016, 93 patients with primary hypopharyngeal squamous cell carcinomas undergoing radical surgery at Fudan University Shanghai Cancer Center were reviewed. The clinicopathological features were analyzed retrospectively. The optimal cutoff values were determined based on the receiver operating characteristic curve analysis. Pearson correlation coefficients were used to assess the correlations between variables. The Kaplan–Meier and Cox proportional hazard methods were used to evaluate the impact of variables on overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Results: Cox multivariate analysis revealed that a depth of invasion (DOI) ≥ 4.3 mm was correlated with inferior OS (P=0.045), DSS (P=0.046), and DFS (P=0.046). A primary tumor volume (PTV) ≥0.36 mL was related to poor OS (P=0.018), DSS (P=0.026), and DFS (P=0.036). A lymph node density (LND) ≥0.07 was also associated with worse OS (P=0.014) and DSS (P=0.045). Moreover, additional prognostic value was observed in the combined use of PTV and LND. Conclusion: The DOI, PTV, and LND obtained from the surgical specimens could provide additional valuable information for prognostic stratification and allowed the more appropriate selection of suitable candidates for more aggressive adjuvant therapy.",
keywords = "Depth of invasion, Hypopharynx, Lymph node density, Primary tumor volume, Surgery, Survival",
author = "Ye, {Lu Lu} and Jia Rao and Fan, {Xing Wen} and Ji, {Qing Hai} and Hu, {Chao Su} and Ying, {Hong Mei}",
year = "2018",
month = "1",
day = "1",
doi = "10.2147/CMAR.S178750",
language = "English (US)",
volume = "10",
pages = "4679--4688",
journal = "Cancer Management and Research",
issn = "1179-1322",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Impact of tumor dimensions and lymph node density on the survival of patients with hypopharyngeal squamous cell carcinoma

AU - Ye, Lu Lu

AU - Rao, Jia

AU - Fan, Xing Wen

AU - Ji, Qing Hai

AU - Hu, Chao Su

AU - Ying, Hong Mei

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: To analyze the potential variables affecting the survival of patients undergoing primary surgery for hypopharyngeal squamous cell carcinoma. Patients and methods: Between August 2007 and December 2016, 93 patients with primary hypopharyngeal squamous cell carcinomas undergoing radical surgery at Fudan University Shanghai Cancer Center were reviewed. The clinicopathological features were analyzed retrospectively. The optimal cutoff values were determined based on the receiver operating characteristic curve analysis. Pearson correlation coefficients were used to assess the correlations between variables. The Kaplan–Meier and Cox proportional hazard methods were used to evaluate the impact of variables on overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Results: Cox multivariate analysis revealed that a depth of invasion (DOI) ≥ 4.3 mm was correlated with inferior OS (P=0.045), DSS (P=0.046), and DFS (P=0.046). A primary tumor volume (PTV) ≥0.36 mL was related to poor OS (P=0.018), DSS (P=0.026), and DFS (P=0.036). A lymph node density (LND) ≥0.07 was also associated with worse OS (P=0.014) and DSS (P=0.045). Moreover, additional prognostic value was observed in the combined use of PTV and LND. Conclusion: The DOI, PTV, and LND obtained from the surgical specimens could provide additional valuable information for prognostic stratification and allowed the more appropriate selection of suitable candidates for more aggressive adjuvant therapy.

AB - Purpose: To analyze the potential variables affecting the survival of patients undergoing primary surgery for hypopharyngeal squamous cell carcinoma. Patients and methods: Between August 2007 and December 2016, 93 patients with primary hypopharyngeal squamous cell carcinomas undergoing radical surgery at Fudan University Shanghai Cancer Center were reviewed. The clinicopathological features were analyzed retrospectively. The optimal cutoff values were determined based on the receiver operating characteristic curve analysis. Pearson correlation coefficients were used to assess the correlations between variables. The Kaplan–Meier and Cox proportional hazard methods were used to evaluate the impact of variables on overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Results: Cox multivariate analysis revealed that a depth of invasion (DOI) ≥ 4.3 mm was correlated with inferior OS (P=0.045), DSS (P=0.046), and DFS (P=0.046). A primary tumor volume (PTV) ≥0.36 mL was related to poor OS (P=0.018), DSS (P=0.026), and DFS (P=0.036). A lymph node density (LND) ≥0.07 was also associated with worse OS (P=0.014) and DSS (P=0.045). Moreover, additional prognostic value was observed in the combined use of PTV and LND. Conclusion: The DOI, PTV, and LND obtained from the surgical specimens could provide additional valuable information for prognostic stratification and allowed the more appropriate selection of suitable candidates for more aggressive adjuvant therapy.

KW - Depth of invasion

KW - Hypopharynx

KW - Lymph node density

KW - Primary tumor volume

KW - Surgery

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=85057736916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057736916&partnerID=8YFLogxK

U2 - 10.2147/CMAR.S178750

DO - 10.2147/CMAR.S178750

M3 - Article

AN - SCOPUS:85057736916

VL - 10

SP - 4679

EP - 4688

JO - Cancer Management and Research

JF - Cancer Management and Research

SN - 1179-1322

ER -