Improving clinical outcomes using adoptively transferred immune cells from umbilical cord blood

Patrick J. Hanley; Conrad Russell Cruz; Elizabeth J. Shpall; Catherine M. Bollard

doi:10.3109/14653249.2010.517518

Improving clinical outcomes using adoptively transferred immune cells from umbilical cord blood

Patrick J. Hanley, Conrad Russell Cruz, Elizabeth J. Shpall, Catherine M. Bollard

Stem Cell Transplantation

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Because of the necessary immunodepletion prior to cord blood transplantation as well as the immaturity of cord blood immune cells, recipients experience a high incidence of viral infection in addition to complications observed after hematopoietic stem cell transplantation, such as relapse and graft-versus-host disease. We describe current immunotherapeutic approaches to treating these complications, including the generation of antigen-specific T cells from cord blood, redirecting cord blood T cells using chimeric antigen receptors, and generating cord blood-derived natural killer cells and regulatory T cells.

Original language	English (US)
Pages (from-to)	713-720
Number of pages	8
Journal	Cytotherapy
Volume	12
Issue number	6
DOIs	https://doi.org/10.3109/14653249.2010.517518
State	Published - Oct 2010

Keywords

Immune reconstitution
Immunotherapy

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology
Genetics(clinical)
Cell Biology
Cancer Research
Transplantation

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10.3109/14653249.2010.517518

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title = "Improving clinical outcomes using adoptively transferred immune cells from umbilical cord blood",

abstract = "Because of the necessary immunodepletion prior to cord blood transplantation as well as the immaturity of cord blood immune cells, recipients experience a high incidence of viral infection in addition to complications observed after hematopoietic stem cell transplantation, such as relapse and graft-versus-host disease. We describe current immunotherapeutic approaches to treating these complications, including the generation of antigen-specific T cells from cord blood, redirecting cord blood T cells using chimeric antigen receptors, and generating cord blood-derived natural killer cells and regulatory T cells.",

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AU - Hanley, Patrick J.

AU - Cruz, Conrad Russell

AU - Shpall, Elizabeth J.

AU - Bollard, Catherine M.

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N2 - Because of the necessary immunodepletion prior to cord blood transplantation as well as the immaturity of cord blood immune cells, recipients experience a high incidence of viral infection in addition to complications observed after hematopoietic stem cell transplantation, such as relapse and graft-versus-host disease. We describe current immunotherapeutic approaches to treating these complications, including the generation of antigen-specific T cells from cord blood, redirecting cord blood T cells using chimeric antigen receptors, and generating cord blood-derived natural killer cells and regulatory T cells.

AB - Because of the necessary immunodepletion prior to cord blood transplantation as well as the immaturity of cord blood immune cells, recipients experience a high incidence of viral infection in addition to complications observed after hematopoietic stem cell transplantation, such as relapse and graft-versus-host disease. We describe current immunotherapeutic approaches to treating these complications, including the generation of antigen-specific T cells from cord blood, redirecting cord blood T cells using chimeric antigen receptors, and generating cord blood-derived natural killer cells and regulatory T cells.

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KW - Immunotherapy

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JO - Cytotherapy

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ER -

Improving clinical outcomes using adoptively transferred immune cells from umbilical cord blood

Abstract

Keywords

ASJC Scopus subject areas

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